A coupled ordinary differential equation lattice model for the simulation of epileptic seizures
A coupled ordinary differential equation lattice model for the simulation of epileptic seizures
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作者：
Larter, R;Speelman, B;Worth, RM
建立了癫痫灶常见部位--海马区CA3区的耦合常微分格模型。该模型由一个六边形节点组成，每个节点描述一个子网络，该子网络由一组典型的兴奋性锥体细胞和一组通过ON/OFF兴奋性和抑制性突触连接的典型抑制性中间神经元组成。这些节点使用简单的规则进行通信，以模拟细胞外钾的扩散。在允许扩散事件发生之前，节点轨迹被积分的积分时间和每个节点的抑制程度都被发现是重要的参数。较短的整合时间导致晶格的完全同步(类似于癫痫发作期间发生的同步神经活动)，而较长的时间导致更随机的时空行为。适度减弱的抑制水平会导致简单的节点振荡行为。据推测，缺乏抑制和传导时间的改变可能是行为显性癫痫的发生所必需的。(C)1999年美国物理研究所。[S1054-1500(99)00403-6]。
A coupled ordinary differential equation lattice model for the CA3 region of the hippocampus (a common location of the epileptic focus) is developed. This model consists of a hexagonal lattice of nodes, each describing a subnetwork consisting of a group of prototypical excitatory pyramidal cells and a group of prototypical inhibitory interneurons connected via on/off excitatory and inhibitory synapses. The nodes communicate using simple rules to simulate the diffusion of extracellular potassium. Both the integration time over which a node's trajectory is integrated before the diffusional event is allowed to occur and the level of inhibition in each node were found to be important parameters. Shorter integration times lead to total synchronization of the lattice (similar to synchronous neural activity occurring during a seizure) whereas longer times cause more random spatiotemporal behavior. Moderately diminished levels of inhibition lead to simple nodal oscillatory behavior. It is postulated that both the lack of inhibition and an alteration in conduction time may be necessary for the development of a behaviorally manifest seizure. (C) 1999 American Institute of Physics. [S1054-1500(99)00403-6].