Functional involvement of central nervous system at high altitude
Functional involvement of central nervous system at high altitude
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DOI：
10.1007/s00221-009-1729-1
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发表时间：
2009-03-01
影响因子：
2
通讯作者：
Oliviero, Antonio
中科院分区：
文献类型：
--
作者：
Miscio, Giacinta;Milano, Eva;Oliviero, Antonio
急性高原反应是未适应的人在上升到高海拔时所经历的一种常见的不适。我们使用经颅磁刺激验证了高海拔暴露影响皮质兴奋性的假说。我们具体分析了正常受试者在高海拔和接近海平面的控制条件下的运动皮质兴奋性。平均静息运动阈值高海拔地区(69.3+/-A10.4vs56.3+/-A10.9%，P=0.042)。平均短时皮质内抑制(SICI)在高原显著低于高原(运动诱发电位测试百分比=79.3+/-A19.8vs28.7+/-A17.5%，P=0.0004)。急性高原反应症状与高原静息运动阈值改变相关(R(2)=0.53，P=0.037)。SaO2与高原SICI变化呈正相关(R(2)=0.45，P=0.036)。我们认为，高原通过影响抑制性和兴奋性回路而深刻改变皮质的兴奋性，这反映在急性高原反应症状上。
Acute mountain sickness is a common discomfort experienced by unacclimatized persons on ascent to high altitude. We tested the hypothesis that exposure to high altitude affects cortical excitability using transcranial magnetic stimulation. We specifically analyzed the motor cortex excitability in normal subjects at high altitude and in a control condition near sea level. Mean resting motor threshold (RMT) was significantly higher at high altitude than at sea level (69.3 +/- A 10.4 versus 56.3 +/- A 10.9%; P = 0.042). Mean short intracortical inhibition (SICI) was significantly lower at high altitude than at sea level (percentage of test motor-evoked potential = 79.3 +/- A 19.8 versus 28.7 +/- A 17.5%; P = 0.0004). Symptoms of acute mountain sickness correlated with resting motor threshold changes induced by high altitude (R (2) = 0.53, P = 0.037). SaO(2) correlated with SICI changes induced by high altitude (R (2) = 0.45, P = 0.036). We suggest that high altitude deeply changes cortical excitability by affecting both inhibitory and excitatory circuits and that this is reflected in acute mountain sickness symptoms.