CONTRAST-ENHANCED NMR IMAGING - ANIMAL STUDIES USING GADOLINIUM-DTPA COMPLEX
CONTRAST-ENHANCED NMR IMAGING - ANIMAL STUDIES USING GADOLINIUM-DTPA COMPLEX
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DOI：
10.2214/ajr.142.3.625
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发表时间：
1984-01-01
影响因子：
5
通讯作者：
WESBEY, GE
中科院分区：
文献类型：
--
作者：
BRASCH, RC;WEINMANN, HJ;WESBEY, GE
通过对正常动物和疾病动物的实验成像，评价了Gd-DTPA[二乙烯三胺五乙酸]络合物作为核磁共振对比剂的作用。静脉注射后。注射Gd-DTPA后，由于未成对的电子，Gd-DTPA是一种强烈的顺磁性络合物，在大鼠的尿液中迅速排出，在肾实质和尿液的核磁共振图像上产生了容易观察到的对比增强。注射0.1 mmol/kg Gd-DTPA后，肾盆内尿液自旋回波强度从2263个单位增加到4414个单位，肾实质信号从2901个单位增加到3893个单位。无菌软组织脓肿表现为明显的边缘强化。在犬模型中，在注射造影剂之前，只有在自旋回波核磁共振图像上才能微弱地检测到辐射诱导的脑损伤的一个病灶。注射0.5 mmol/kg Gd-DTPA后，损伤强度由3867增加到5590。相比之下，血脑屏障完整的正常脑在核磁共振表征中没有变化。Gd-DTPA是一种很有前途的新型核磁共振对比剂，可用于临床评估肾功能、炎性病变和血脑屏障的局灶性破坏。
Gd-DTPA [diethylenetriaminepentaacetic acid] complex was assessed as NMR contrast-enhancing agent by experimentally imaging normal and diseased animals. After i.v. injection, Gd-DTPA, a strongly paramagnetic complex by virtue of unpaired electrons, was rapidly excreted into the urine of rats, producing an easily observable contrast enhancement on NMR images in kidney parenchyma and urine. Spin-echo intensity of urine within the renal pelvis increased from 2263 to 4414 units; intensity of renal parenchyma increased from 2901 to 3893 after administration of 0.1 mmol/kg Gd-DTPA. Sterile soft-tissue abscesses demonstrated an obvious rim pattern of enhancement. A focus of radiation-induced brain damage in a canine model was only faintly detectable on spin-echo NMR images before contrast administration. After 0.5 mmol/kg Gd-DTPA administration, the lesion intensity increased from 3867 to 5590. In comparison, the normal brain with an intact blood-brain barrier remained unchanged in NMR characterization. Gd-DTPA is a promising new NMR contrast enhancer for the clinical assessment of renal function, inflammatory lesions and focal disruption of the blood-brain barrier.