Cortical mapping of genotype-phenotype relationships in schizophrenia
Cortical mapping of genotype-phenotype relationships in schizophrenia
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DOI：
10.1002/hbm.20404
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发表时间：
2007-06-01
影响因子：
4.8
通讯作者：
Cannon, Tyrone D.
中科院分区：
文献类型：
--
作者：
Bearden, Carrie E.;van Erp, Theo G. M.;Cannon, Tyrone D.
尽管精神分裂症具有高度遗传性，但寻找易感基因一直具有挑战性。“内表型”方法是测量表型变异的另一种方法，它可能使在复杂遗传性状的背景下更容易识别易感基因。神经成像方法尤其为基因和行为的神经生物学提供了一个强大的桥梁。这样的研究可能会通过涉及与精神分裂症相关的染色体异常的补充策略得到进一步的授权，这可以帮助定位致病基因并更好地了解疾病的遗传复杂性。在这里，我们说明了我们对这些收敛方法的使用，重点是使用新颖的计算脑映射算法进行神经成像研究，以研究精神病发展中遗传对大脑结构的影响。这些研究提供了令人信服的证据，表明被怀疑易患精神分裂症的特定基因位点可能影响神经行为表型下神经指标的定量变化，并说明了遗传-神经影像学范式如何提高我们对这种高度致残精神疾病发病机制的理解。
Although schizophrenia is highly heritable, the search for susceptibility genes has been challenging. The "endophenotype" approach is an alternative method for measuring phenotypic variation that may make it easier to identify susceptibility genes in the context of complexly inherited traits. Neuroimaging methods in particular offer a powerful way to bridge the neurobiology of genes and behavior. Such investigations may be further empowered by complementary strategies involving chromosomal abnormalities associated with schizophrenia, which can help to localize causative genes and better understand the genetic complexity of the illness. Here, we illustrate our use of these convergent approaches, with a focus on neuroimaging studies using novel computational brain mapping algorithms, to investigate genetic influences on brain structure in the development of psychosis. These studies provide compelling evidence that specific genetic loci suspected to predispose to schizophrenia may affect quantitative variation in neural indicators underlying the neurobehavioral phenotype, and illustrate how genetic-neuroimaging paradigms can improve our understanding of the pathogenesis of this highly disabling mental illness.