Vascular endothelial growth factor serum levels in pregnancy and preeclampsia
Vascular endothelial growth factor serum levels in pregnancy and preeclampsia
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DOI：
10.1034/j.1600-0412.2000.079001077.x
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发表时间：
2000-01-01
影响因子：
4.3
通讯作者：
Tempfer, C
中科院分区：
文献类型：
--
作者：
Hefler, L;Obermair, A;Tempfer, C
先兆子痫（PE）是妊娠期最常见的医学并发症之一，也是全球孕产妇和围产期发病率和死亡率的重要原因。尽管PE的临床重要性，这种疾病的病理生理机制仍有待阐明。据推测，血管内皮生长因子（VEGF）通过引起内皮细胞改变，参与PE的自然病程（1，2）。然而，VEGF血清水平在妊娠和PE中的作用一直存在争议。Baker等人报告称，与健康孕妇相比，PE女性的VEGF血清水平升高（1）。相反，Lyall等人证明，与健康非妊娠女性相比，健康妊娠女性的VEGF血清水平降低，并且在PE女性中进一步降低（3）。安东尼等人，然而，研究表明，与健康非妊娠女性相比，健康妊娠女性的VEGF血清水平升高（4）。本研究的目的是评估VEGF血清水平在46名妇女与PE和46名健康孕妇，匹配的年龄和胎次方面的临床实用性，这种血清标志物作为PE的分化和预后标志物。此外，在一组130名健康非妊娠妇女中测定VEGF血清水平。用于血清测量缩略语：
Preeclampsia (PE) is one of the most common medical complications of pregnancy and an important cause of maternal and perinatal morbidity and mortality worldwide. Despite the clinical importance of PE, the pathophysiological mechanisms of this disease remain to be elucidated. It has been speculated that vascular endothelial growth factor (VEGF), by causing endothelial cell alteration, is involved in the natural history of PE (1, 2). The role of VEGF serum levels in pregnancy and PE, however, has been discussed controversially. Baker et al. reported that VEGF serum levels are elevated in women with PE compared to healthy pregnant women (1). In contrast, Lyall et al. demonstrated that VEGF serum levels are reduced in healthy pregnant women compared to healthy non-pregnant women, and are further reduced in women with PE (3). Anthony et al., however, showed that VEGF serum levels are increased in healthy pregnant women compared to healthy non-pregnant women (4). The aim of the present study was to evaluate VEGF serum levels in 46 women with PE and 46 healthy pregnant women, matched for age and parity with respect to the clinical usefulness of this serum marker as differentiation and prognostic marker of PE. Furthermore, VEGF serum levels were determined in a panel of 130 healthy nonpregnant women. For the measurement of serumAbbreviations: