On Spontaneous Mutation.
On Spontaneous Mutation.
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DOI：
10.1073/pnas.30.10.297
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发表时间：
1944-10
影响因子：
11.1
通讯作者：
Richard Goldschmidt
中科院分区：
文献类型：
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作者：
Richard Goldschmidt
黑藻菌孢子萌发时，1-甲基鸟嘌呤接近活性鸟嘌呤本身，而其他甲基鸟嘌呤和密切相关的化合物具有较低数量级的活性。(未发表的Wm实验。j·罗宾斯)。由于1位的甲基化会导致内酰胺互变异构体的固定，因此可以推测，在鸟嘌呤酶和藻菌中，具有活性的是鸟嘌呤的内酰胺形式。希钦斯，g.h.和菲斯克，c.h., Jour。医学杂志。化学。， 41, 827-835（1941）。
germination of spores of Phycomyces blakesleanus, 1-methylguanine approaches in activity guanine itself where other methyl guanines and closely related compounds have activities of a lower order of magnitude. (Unpublished experiments with Wm. J. Robbins.) Since methylation in the 1-position would result in fixation of the lactam tautomer, it is perhaps permissible to speculate that with guanase and with Phycomyces it is the lactam form of guanine which is active. Hitchings, G. H., and Fiske, C. H., Jour. Biol. Chem., 141, 827-835 (1941).