Baseline Association of Motoric Cognitive Risk Syndrome With Sustained Attention, Memory, and Global Cognition
Baseline Association of Motoric Cognitive Risk Syndrome With Sustained Attention, Memory, and Global Cognition
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DOI：
10.1016/j.jamda.2017.07.016
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发表时间：
2018-01-01
影响因子：
7.6
通讯作者：
Reilly, Richard B.
中科院分区：
文献类型：
--
作者：
Maguire, Fiachra J.;Killane, Isabelle;Reilly, Richard B.
目的：缓慢的步态已被证明是健康老年人认知功能下降的一个很好的预测因素。运动性认知风险（MCR）综合征是一种新的结构，包括步态缓慢和主观认知投诉的个人没有痴呆谁保留了日常生活活动。该分析调查了全国代表性人群中MCR的患病率和与MCR相关的因素。此外，横截面之间的关联MCR和认知领域，尚未完全阐明的关系在literature，investigated.Measurements：参与者完成了全面的神经心理学评估和步态分析在健康评估中心。Logistic回归分析相关的健康因素。综合分数反映全球认知，记忆，持续注意力，执行功能，和处理速度构建使用神经心理学测试分数。MCR和这些复合材料之间的关联进行了量化，使用多变量广义线性模型。所有的分析加权是nationally representatively.Setting：社区居住的成年人在爱尔兰老龄化纵向研究（TILDA）完成了一个采访和一个中心为基础的健康assessment.Participants：参与者年龄在60岁及以上（n = 2151，年龄;平均值：67.84岁，范围：60-93）。参与者的简易精神状态检查分数低于24，诊断为严重的记忆障碍，帕金森病，痴呆症，或阿尔茨海默病excluded.Results：MCR患病率估计为2.56%（95%置信区间1.97，3.31）。MCR的显著危险因素是抗抑郁药使用[比值比（OR）4.46，P <0.001]，自我报告的视力不良（OR 4.92，P <0.05）和肥胖（OR 2.29，P <0.01）。患有MCR的人在评估记忆力的测试中表现更差（B：-0.58，P < .001），整体认知（B：-0.42，P < .001），持续注意（B：-0.34，P <0.05），并对混杂的人口统计学和健康变量进行了稳健的调整。这可能表明MCR的基础病理学。抗抑郁药对MCR的影响是新的，可能是未来研究的重要考虑因素。(C)2017年AMDA -急性后和长期护理医学协会。
Objectives: Slow gait has been shown to be a good predictor of declining cognitive function in healthy older adults. Motoric cognitive risk (MCR) syndrome is a new construct incorporating slow gait and subjective cognitive complaints in individuals without dementia who have preserved activities of daily living. This analysis investigated the prevalence of MCR and factors associated with MCR in a nationally representative population. In addition, cross-sectional associations between MCR and cognitive domains, an relationship yet to be fully elucidated in literature, was investigated.Measurements: Participants completed a comprehensive neuropsychological assessment and gait analysis at a health assessment center. Logistic regression was employed to examine associated health factors. Composite scores reflecting global cognition, memory, sustained attention, executive function, and processing speed were constructed using neuropsychological test scores. Associations between MCR and these composites were quantified using multivariate generalized linear modelling. All analyses were weighted to be nationally representative.Setting: Community-dwelling adults in The Irish Longitudinal Study on Aging (TILDA) completed an interview and a center-based health assessment.Participants: Participants aged 60 years and over (n = 2151, age; mean: 67.84 years, range: 60-93) were included. Participants with a Mini-Mental State Examination score of below 24, a diagnosis of serious memory impairment, Parkinson disease, dementia, or Alzheimer disease were excluded.Results: MCR prevalence was estimated at 2.56% (95% confidence interval 1.97, 3.31). Significant risk factors for MCR were antidepressant use [odds ratio (OR) 4.46, P < .001], self-reported poor vision (OR 4.92, P < .05), and obesity (OR 2.29, P < .01). Individuals with MCR performed worse on tests that assess memory (B: -0.58, P < .001), global cognition (B: -0.42, P < .001), and sustained attention (B: -0.34, P < .05) with robust adjustment made for confounding demographic and health variables.Conclusions: MCR is characterized by strong negative associations with global cognition, attention, and memory. This may be indicative of the underlying pathology of MCR. The effect of antidepressant use on MCR is novel and may represent an important consideration in future studies. (C) 2017 AMDA - The Society for Post-Acute and Long-Term Care Medicine.