Insulins: Past, Present, and Future
Insulins: Past, Present, and Future
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DOI：
10.1016/j.ecl.2012.03.002
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发表时间：
2012-03-01
影响因子：
4.5
通讯作者：
Zinman, Bernard
中科院分区：
文献类型：
--
作者：
Borgono, Carla A.;Zinman, Bernard
本文重点介绍了胰岛素发现及其作为糖尿病关键疗法的持续发展的选定里程碑。过去 90 年见证了胰岛素治疗的巨大进步，从最初的粗制但可挽救生命的动物胰岛素提取物到新型人胰岛素类似物。尽管开环皮下注射胰岛素本质上难以实现胰岛素的完全生理替代，但持续开发具有优异药代动力学和药效学的改进注射胰岛素制剂将增强血糖控制，并代表了 1 型和 2 型糖尿病治疗的重要临床进展。
This article highlights selected milestones in insulin discovery and its continued development as a pivotal therapy for diabetes. The last 90 years have witnessed tremendous progress in insulin therapy, from the initial crude, yet life-saving, animal insulin extracts to novel human insulin analogues. Although the complete physiologic replacement of insulin is inherently difficult to achieve with open-loop subcutaneously administered insulin, the continued development of improved injectable insulin formulations with superior pharmacokinetics and pharmacodynamics will enhance glucose control, and represents important clinical advances in the treatment of both type 1 and type 2 diabetes.