Role of the dorsomedial striatum in behavioral flexibility for response and visual cue discrimination learning.
Role of the dorsomedial striatum in behavioral flexibility for response and visual cue discrimination learning.
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DOI：
10.1037//0735-7044.116.1.105
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发表时间：
2002-02
影响因子：
1.9
通讯作者：
M. Ragozzino;Katharine E. Ragozzino;S. Mizumori;R. Kesner
中科院分区：
文献类型：
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作者：
M. Ragozzino;Katharine E. Ragozzino;S. Mizumori;R. Kesner
这些实验考察了背内侧纹状体失活对反应和视觉线索辨别任务的获得的影响，以及从反应到视觉线索辨别的转换，反之亦然。在实验1中，对大鼠进行了反应辨别任务和视觉线索辨别任务。在实验2中，测试顺序颠倒了。注射2%丁卡因不会损害反应或视觉线索辨别的获得，但会损害从反应转向视觉线索辨别时的表现，反之亦然。对错误的分析表明，赤字不是由于坚持以前学到的战略，而是由于无法维持新战略。这些结果与研究结果相反，研究结果表明，初步失活会由于坚持先前学到的策略而损害行为灵活性。因此，前额叶皮质和纹状体中的特定回路可能相互作用，以实现行为灵活性，但每个区域可能有助于促进策略转换的不同过程。
These experiments examined the effects of dorsomedial striatal inactivation on the acquisition of a response and visual cue discrimination task, as well as a shift from a response to a visual cue discrimination, and vice versa. In Experiment 1, rats were tested on the response discrimination task followed by the visual cue discrimination task. In Experiment 2, the testing order was reversed. Infusions of 2% tetracaine did not impair acquisition of the response or visual cue discrimination but impaired performance when shifting from a response to a visual cue discrimination, and vice versa. Analysis of the errors revealed that the deficit was not due to perseveration of the previously learned strategy, but to an inability to maintain the new strategy. These results contrast with findings indicating that prelimbic inactivation impairs behavioral flexibility due to perseveration of a previously learned strategy. Thus, specific circuits in the prefrontal cortex and striatum may interact to enable behavioral flexibility, but each region may contribute to distinct processes that facilitate strategy switching.