INNERVATION OF THE LARYNX, PHARYNX, AND UPPER ESOPHAGEAL SPHINCTER OF THE RAT
INNERVATION OF THE LARYNX, PHARYNX, AND UPPER ESOPHAGEAL SPHINCTER OF THE RAT
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DOI：
10.1002/cne.903490109
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发表时间：
1994-11-01
影响因子：
2.5
通讯作者：
BENECCHI, EJ
中科院分区：
文献类型：
--
作者：
KOBLER, JB;DATTA, S;BENECCHI, EJ
我们在咽食管交界处确定了大鼠甲咽肌的“半圆形”隔室，并使用糖原消耗方法来确定该肌肉的纤维（以及咽和喉的所有其他肌肉）如何受到不同颅神经分支的神经支配。半圆形室在解剖学上与人类环咽肌相似，环咽肌是上食管括约肌的重要组成部分。虽然我们发现咽和喉内的咽部、喉上神经和喉返神经的肌肉目标几乎没有重叠，但半圆肌接受来自两个迷走神经分支的双重、指状神经支配：咽神经和喉上神经的一个分支，我们称为背侧副支。将辣根过氧化物酶应用于这两条神经后，我们比较了脑干中标记的细胞的分布和数量。背侧副支比咽神经传递更异质的传出纤维，包括咽和食管运动神经元以及副交感节前神经元的轴突。观察到的疑核中标记的运动神经元的分布也使我们认为半圆形室由两个运动神经元子集支配，其中一个子集位于主咽运动柱的腹外侧。这种排列提出了半圆形室运动神经元之间的功能差异与观察到的细胞体脑干位置差异相关的可能性。 (C) 1994 年 Wiley-Liss 公司
We identified a 'semicircular' compartment of the rat thyropharyngeus muscle at the pharyngoesophageal junction and used the glycogen depletion method to determine how the fibers of this muscle (as well as all others of the pharynx and larynx) are innervated by different cranial nerve branches. The semicircular compartment appears anatomically homologous to the human cricopharyngeus muscle, an important component of the upper esophageal sphincter. While we found very little overlap in the muscle targets of the pharyngeal, superior laryngeal and recurrent laryngeal nerves within the pharynx and larynx, the semicircular muscle receives a dual, interdigitating innervation from two vagal branches: the pharyngeal nerve and a branch of the superior laryngeal nerve we call the dorsal accessory branch. After applying horseradish peroxidase to either of these two nerves, we compared the distribution and number of cells labeled in the brainstem. The dorsal accessory branch conveys a more heterogeneous set of efferent fibers than does the pharyngeal nerve, including the axons of pharyngeal and esophageal motor neurons and parasympathetic preganglionic neurons. The observed distribution of labeled motor neurons in nucleus ambiguus also leads us to suggest that the semicircular compartment is innervated by two subsets of motor neurons, one of which is displaced ventrolateral to the main pharyngeal motor column. This arrangement raises the possibility of functional differences among semicircular compartment motor neurons correlated with the observed differences in brainstem location of cell bodies. (C) 1994 Wiley-Liss, Inc.