IL-6 helps weave the inflammatory web during acute coronary syndromes.
IL-6 helps weave the inflammatory web during acute coronary syndromes.
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DOI：
10.1172/jci167670
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发表时间：
2023-06-01
影响因子：
15.9
通讯作者：
Libby, Peter
中科院分区：
文献类型：
--
作者：
Nakao, Tetsushi;Libby, Peter
细胞因子IL-6在衰老和缺血性心脏病中具有众所周知的促炎作用。在这一期的JCI中，Alter和他的同事使用小鼠实验和人体组织来研究心肌梗死后IL-6的来源。作者发现，在小鼠冠状动脉结扎后，心脏成纤维细胞产生IL-6，并提出存在通过腺苷A2B受体参与腺苷信号转导的途径。这些发现强调了IL-6生物学在缺血性心脏病中的复杂性，并确定了腺苷/IL-6途径，值得考虑将其作为心血管风险的调节因子。
The cytokine IL-6 has well-known proinflammatory roles in aging and ischemic heart disease. In this issue of the JCI, Alter and colleagues used mouse experiments and human tissue to investigate the source of IL-6 following myocardial infarction. The authors showed that cardiac fibroblasts produced IL-6 after coronary ligation in mice and proposed the existence of a pathway involving adenosine signaling via the adenosine A2b receptor. The findings underscore the complexity of IL-6 biology in ischemic heart disease and identify an adenosine/IL-6 pathway that warrants consideration for targeting as a modulator of cardiovascular risk.