No viral Evolution in the lymph Nodes of Simian Immunodecifiency Virus-Infected Rhesus Macaaues during Combined Antiretroviral Therapy
No viral Evolution in the lymph Nodes of Simian Immunodecifiency Virus-Infected Rhesus Macaaues during Combined Antiretroviral Therapy
复制标题
联合抗逆转录病毒治疗期间感染猿猴免疫缺陷病毒的恒河猴淋巴结无病毒进化
作者：
Oue M;et al.
为了阐明联合抗逆转录病毒治疗（cART）期间灵长类慢病毒感染个体中病毒持续存在的模式，对4只猴免疫缺陷病毒239感染的猴进行了1年的cART治疗。通过单基因组扩增评估从治疗完成时收集的肠系膜淋巴结提取的总RNA制备的viralenvegene。核苷酸替换和同源性分析显示cART期间无病毒进化。
To elucidate the mode of viral persistence in primate lentivirus-infected individuals during combination antiretroviral therapy (cART), four simian immunodeficiency virus 239-infected monkeys were treated with cART for 1 year. The viralenvgenes prepared from total RNA extracted from the mesenteric lymph nodes collected at the completion of therapy were assessed by single genome amplification. Analyses of nucleotide substitutions and phylogeny revealed no viral evolution during cART.