Aging alters feedback effects of the activity-rest cycle on the circadian clock.
Aging alters feedback effects of the activity-rest cycle on the circadian clock.
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衰老会改变活动-休息周期对生物钟的反馈影响。
DOI：
10.1152/ajpregu.1992.263.4.r981
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Turek,FW
中科院分区：
文献类型：
--
作者：
VanReeth,O;Zhang,Y;Zee,PC;Turek,FW
两种不同的刺激（即，苯二氮卓类和暗脉冲）通过活动水平的变化诱导年轻仓鼠的昼夜节律钟的相移，但这些刺激不会诱导老年仓鼠的相移，尽管事实上这些刺激诱导年轻和老年动物的运动活动的类似急性变化。相比之下，老年仓鼠对明显与运动活动的任何变化无关的刺激的相移效应保持敏感（即，蛋白质合成抑制剂或光）。因此，老年动物的昼夜节律系统变得对由动物的活动-休息状态介导的同步信号选择性地无反应。在哺乳动物（包括人类）中观察到的与年龄相关的昼夜节律变化可能与活动-休息周期和昼夜节律钟之间的耦合减弱有关。
Two different stimuli (i.e., benzodiazepines and dark pulses) inducing phase shifts in the circadian clock of young hamsters through changes in the level of activity do not induce phase shifts in old hamsters, despite the fact that these stimuli induce a similar acute change in locomotor activity in young and old animals. In contrast, old hamsters remain sensitive to the phase-shifting effects of stimuli clearly not associated with any change in locomotor activity (i.e., protein synthesis inhibitors or light). Thus the circadian system of old animals becomes selectively unresponsive to synchronizing signals mediated by the activity-rest state of the animals. Previous age-related changes in circadian rhythmicity that have been observed in mammals, including humans, may be related to a weakened coupling between the activity-rest cycle and the circadian clock.