Line of therapy and patient preferences regarding lung cancer treatment: a discrete-choice experiment
Line of therapy and patient preferences regarding lung cancer treatment: a discrete-choice experiment
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DOI：
10.1080/03007995.2021.1888707
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发表时间：
2021-02-15
影响因子：
2.3
通讯作者：
Bridges, John F. P.
中科院分区：
文献类型：
--
作者：
Janse, Sarah;Janssen, Ellen;Bridges, John F. P.
越来越多关于患者偏好的文献为研究决策、监管科学和价值评估提供信息，但很少有研究探讨不同治疗经历的患者偏好如何变化。我们试图量化患者对肺癌治疗的获益和风险的偏好，并测试不同治疗线（LOT）的偏好差异。方法采用离散选择实验（DCE），在严格的患者和利益相关者参与后引出参考文献。DCE涵盖五个属性（每个属性都有三个级别）：无进展生存期（PFS）、短期副作用、长期副作用、发生迟发性副作用的风险和给药模式（MOA），每个属性都在三个相关级别上定义。采用d效率设计生成3个调查块，每个调查块由9个配对的个人资料选择任务组成，受访者被问及他们更喜欢哪种个人资料，然后他们是否更喜欢不接受治疗（选择退出）。一个混合logit模型，控制选择退出，被用来估计偏好。在两组之间比较PFS和其他属性之间的偏好和权衡：接受= 2 LOT的组。结果在466名参与者中，42%的人接受了= 2 LOT。总的来说，两组之间陈述的偏好不同(p
ObjectiveA growing literature on patient preferences informs decisions in research, regulatory science, and value assessment, but few studies have explored how preferences vary across patients with differing treatment experience. We sought to quantify patient preferences for the benefits and risks of lung cancer treatment and test how preferences differed by line of therapy (LOT).MethodsPreferences were elicited using a discrete choice experiment (DCE) following rigorous patient and stakeholder engagement. The DCE spanned five attributes (each with three levels): progression-free survival (PFS), short-term side effects, long-term side effects, risk of developing late-onset side effects, and mode of administration (MOA) - each defined across 3 relevant levels. A D-efficient design was used to generate 3 survey blocks of 9 paired-profile choice tasks each and respondents were asked which profile they preferred and then if they preferred to have no treatment (opt-out). A mixed logit model, controlling for opt-out, was used to estimate preferences. Preferences and trade-offs between PFS and other attributes were compared across two groups: those receiving = 2 LOT.ResultsOf the 466 participants, 42% received = 2 LOT. Stated preferences differed between the groups overall (p