Activity of alcohol dehydrogenase and acetaldehyde dehydrogenases in the liver and placenta during the development of the rat.
Activity of alcohol dehydrogenase and acetaldehyde dehydrogenases in the liver and placenta during the development of the rat.
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大鼠发育过程中肝脏和胎盘中乙醇脱氢酶和乙醛脱氢酶的活性。
DOI：
10.1159/000458560
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
J. Mørland
中科院分区：
文献类型：
--
作者：
M. Sjöblom;L. Pilström;J. Mørland
观察了乙醇脱氢酶（ADH）和乙醛脱氢酶（ALDH I和II）在大鼠体内的发育情况。ADH可以在出生前检测到，并逐渐增加，在47天达到成人值的82%。ALDH I和II从妊娠第15天开始出现，出生时迅速增加，在第47天达到成虫值的80-90%。在个体发生过程中，ALDH和ADH活性之比逐渐降低。所有酶的相对亚细胞分布在出生前、出生后7天和成人中是相同的。在妊娠15和20 d时测定胎盘中ADH和ALDH I、II的活性。胎盘中未检出ADH。妊娠第15天胎盘中ALDH I和ALDH II活性较低，妊娠第20天胎盘中ALDH I和ALDH II活性更低。
The ontogenetic development of the enzymes alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenases (ALDH I and II) was followed in rats. ADH could be detected just before birth and increased gradually to reach 82% of adult values at 47 days. ALDH I and II were present from day 15 of gestation, increased rapidly at birth, and reached 80-90% adult values at 47 days. The ratio between ALDH and ADH activities decreased gradually during ontogenesis. The relative subcellular distribution of all enzymes was identical before birth, 7 days after birth and in adults. The placental activities of ADH and ALDH I and II were studied at 15 and 20 days of pregnancy. ADH could not be detected in placentas. Low activities of ALDH I and II were present in placentas studied at 15 days of gestation, and still lower activities were found in placenta at 20 days.