Intra-aneurysmal hemodynamics in a large middle cerebral artery aneurysm with wall atherosclerosis
Intra-aneurysmal hemodynamics in a large middle cerebral artery aneurysm with wall atherosclerosis
复制标题
DOI：
10.1016/j.surneu.2008.03.035
复制
发表时间：
2008-11-01
影响因子：
--
通讯作者：
Vinuela, Fernando
中科院分区：
文献类型：
--
作者：
Tateshima, Satoshi;Tanishita, Kazuo;Vinuela, Fernando
背景：血流动力学刺激诱导的动脉细胞外基质重塑参与了颈动脉和脑动脉的动脉粥样硬化过程。关于脑动脉瘤本身的动脉粥样硬化改变与其动脉瘤内血流动力学之间的关系的信息很少。方法：手术探查的大型大脑中动脉动脉瘤表现为广泛的动脉粥样硬化改变。在动脉瘤壁上。该动脉瘤的计算机断层血管成像被用来建立体外动脉瘤模型。该模型被用于使用粒子成像测速仪和LDV进行动脉瘤内血流测量。比较动脉粥样硬化区和无动脉斑块区的动脉内血流动力学变化。结果：动脉粥样硬化斑块区没有观察到管壁切应力的高振荡。但无动脉粥样硬化区的室壁切应力的大小明显高于动脉粥样硬化区(P<0.05)。
Background: The remodeling of arterial extra-cellular matrix induced by hemodynamic stimuli is involved in the process of atherosclerosis in the carotid and cerebral arteries. Scarce information is available on the relationship between atherosclerotic changes in brain aneurysms itself and its intra-aneurysmal hemodynamics.Methods: Surgical exploration of a large MCA aneurysm depicted extensive atherosclerotic changes. in the aneurysm wall. Computational tomographic angiography of this aneurysm was used to create an in vitro aneurysm model. This model was used to perform intra-aneurysmal flow measurement using particle imaging velocimetry and LDV. Intra-aneurysmal hemodynamic pattern with wall shear stress distribution was compared between areas with and without atherosclerotic changes.Results: No high oscillation of wall shear stress was observed on the atherosclerotic plaque area. However, the magnitude of wall shear stress tended to be higher in the area without atherosclerotic changes than the area with those changes (P