Sleep Duration and Mortality According to Health Status in Older Adults
Sleep Duration and Mortality According to Health Status in Older Adults
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DOI：
10.1111/j.1532-5415.2010.03071.x
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发表时间：
2010-10-01
影响因子：
6.3
通讯作者：
Rodriguez-Artalejo, Fernando
中科院分区：
文献类型：
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作者：
Eumann Mesas, Arthur;Lopez-Garcia, Esther;Rodriguez-Artalejo, Fernando
目的：根据老年人的身体和精神健康状况，检查日常睡眠时间与死亡率之间的关系。研究背景：2001年至2008年进行的前瞻性研究。参与者：西班牙60岁及以上非机构人群的3,820名代表。测量：基线时自我报告睡眠时间。使用考克斯回归进行分析，并对主要混杂因素进行调整。然后，根据健康状况的许多指标对分析进行分层。睡眠8小时的人死亡率更高（相对风险（RR）=1.34，95%置信区间（CI）=1.02-1.76），9小时（RR 1.48，95% CI=1.12-1.96），10小时（RR 1.73，95% CI=1.30-2.29）和≥ 11小时（RR 1.66，95%CI =1.23-2.24）（趋势P = 10 vs 7小时），即使在健康状况良好的人群中也观察到死亡率：最佳的自认为健康，良好的认知功能（简易精神状态检查评分> 27），无抑郁，生活质量高于队列中位数（医学结局研究36项简表调查身体成分总分>= 46，精神成分总分>= 52），并且在日常生活的工具性活动中没有残疾。睡眠6小时或更少是没有相关的死亡率高于睡眠7小时的人与良好的healthstatus.CONCLUSIONSelf-reported睡眠时间与7年的死亡率在这个队列的老年人，即使调整健康状况。需要进一步的研究来确定这些发现的机制和临床意义。
OBJECTIVESTo examine the association between usual sleep duration and mortality according to physical and mental health status in older adults.DESIGNProspective study conducted from 2001 to 2008.SETTINGCommunity-based study.PARTICIPANTSCohort study of 3,820 persons representative of the noninstitutionalized population aged 60 and older in Spain.MEASUREMENTSSleep duration was self-reported at baseline. Analyses were performed using Cox regression and adjusted for the main confounders. The analyses were then stratified according to numerous indicators of health status.RESULTSDuring follow-up, 897 persons died. Mortality was higher in those who slept 8 hours (relative risk (RR)=1.34, 95% confidence interval (CI)=1.02-1.76), 9 hours (RR 1.48, 95% CI=1.12-1.96), 10 hours (RR 1.73, 95% CI=1.30-2.29) and 11 hours or more (RR 1.66, 95% CI=1.23-2.24) than in those who slept 7 hours (P for trend = 10 vs 7 hours) and mortality was observed even in persons with good health status: optimal perceived health, good cognitive function (Mini-Mental State Examination score > 27), no depression, quality of life better than the cohort median (Medical Outcomes Study 36-item Short Form Survey Physical Component Summary score >= 46 and Mental Component Summary score >= 52), and without disability in instrumental activities of daily living. Sleeping 6 hours or less was not associated with higher mortality than sleeping 7 hours in persons with good health status.CONCLUSIONSelf-reported sleep duration was associated with 7-year mortality in this cohort of older adults, even when adjusted for health status. Further research is needed to determine the mechanisms and clinical implications of these findings.