Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect.
Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect.
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具有细胞毒作用的新型7-氧代和7-羟基三氟秋水仙素类化合物的合成。
DOI：
10.1016/j.bmc.2012.02.043
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发表时间：
2012
影响因子：
3.5
通讯作者：
P. Dallemagne
中科院分区：
文献类型：
--
作者：
E. Chosson;F. Santoro;Christophe Rochais;Jana Sopkova;Rémi Legay;S. Thoret;T. Cresteil;M. Sinicropi;T. Besson;P. Dallemagne
通过邻苯基-β-苯丙氨酸的分子内环化反应合成了7-氧代和7-羟基三氟别秋水仙碱。评价所得化合物对KB细胞的细胞毒活性和对微管蛋白聚合的抑制作用。结果产生了一些有效的细胞毒性化合物与相关的部分抗微管蛋白作用。
The synthesis of 7-oxo and 7-hydroxy trifluoroallocolchicinoids was achieved through the intramolecular cyclization of o-phenyl-β-phenylalanines. The resulting compounds were evaluated for their cytotoxic activity against KB cells and their inhibitory effect towards the polymerization of tubulin. The results yielded some potent cytotoxic compounds with correlated partial antitubulin effect.
影响因子：
2.9
作者：
Andreu, JM;Perez-Ramirez, B;Timasheff, SN
通讯作者：
Timasheff, SN