Water-mediated structuring of bone apatite.
Water-mediated structuring of bone apatite.
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DOI：
10.1038/nmat3787
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发表时间：
2013-12
期刊：
影响因子：
41.2
通讯作者：
Yan Wang;S. Von Euw;F. M. Fernandes;Sophie Cassaignon;M. Selmane;G. Laurent;G. Péhau-Arnaudet;C. Coelho;L. Bonhomme-Coury;M. Giraud‐Guille;F. Babonneau;T. Azaïs;Nadine Nassif
中科院分区：
文献类型：
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作者：
Yan Wang;S. Von Euw;F. M. Fernandes;Sophie Cassaignon;M. Selmane;G. Laurent;G. Péhau-Arnaudet;C. Coelho;L. Bonhomme-Coury;M. Giraud‐Guille;F. Babonneau;T. Azaïs;Nadine Nassif
众所周知，脊椎动物钙化组织的细胞外基质中的有机分子在磷灰石矿物的结构化中是必不可少的，在这里，我们表明水也起着结构化的作用。通过使用固态核磁共振，广角X射线散射和低温透射电子显微镜来表征晶体和仿生磷灰石纳米颗粒以及完整的骨样品的结构和组织，我们证明了水通过无定形磷酸钙层来定向磷灰石晶体，该层覆盖骨磷灰石的结晶核心。这种无序层让人想起在体内各种天然复合材料中钙化生物矿物的晶体核心周围发现的那些。这项工作提供了一个扩展的局部模型的骨生物矿化。
It is well known that organic molecules from the vertebrate extracellular matrix of calcifying tissues are essential in structuring the apatite mineral. Here, we show that water also plays a structuring role. By using solid-state nuclear magnetic resonance, wide-angle X-ray scattering and cryogenic transmission electron microscopy to characterize the structure and organization of crystalline and biomimetic apatite nanoparticles as well as intact bone samples, we demonstrate that water orients apatite crystals through an amorphous calcium phosphate-like layer that coats the crystalline core of bone apatite. This disordered layer is reminiscent of those found around the crystalline core of calcified biominerals in various natural composite materialsin vivo. This work provides an extended local model of bone biomineralization.