Models for the retention of duplicate genes and their biological underpinnings.
Models for the retention of duplicate genes and their biological underpinnings.
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DOI：
10.12688/f1000research.141786.1
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发表时间：
2023
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基因组中的基因内容通过几个不同的过程发生变化，基因复制是这种变化的重要贡献者。基因复制发生在从单个基因到整个基因组的一系列尺度上，并且该过程的动力学可以依赖于上下文。尽管如此，基因在复制后从基因组中保留或丢失的规则仍然存在，并且概率建模已经能够表征这些规则，包括它们的上下文依赖性。在这里，我们描述了生物学和相应的数学模型，用于理解重复基因保留及其对基因组中编码的生化功能的贡献。
Gene content in genomes changes through several different processes, with gene duplication being an important contributor to such changes. Gene duplication occurs over a range of scales from individual genes to whole genomes, and the dynamics of this process can be context dependent. Still, there are rules by which genes are retained or lost from genomes after duplication, and probabilistic modeling has enabled characterization of these rules, including their context-dependence. Here, we describe the biology and corresponding mathematical models that are used to understand duplicate gene retention and its contribution to the set of biochemical functions encoded in a genome.