A major gene model of adult height is suggested in Chinese
A major gene model of adult height is suggested in Chinese
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DOI：
10.1007/s10038-004-0125-8
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发表时间：
2004-03-01
影响因子：
3.5
通讯作者：
Deng, HW
中科院分区：
文献类型：
--
作者：
Li, MX;Liu, PY;Deng, HW
成年身高作为一个复杂的数量性状，在不同的群体中进行了研究。然而，很少有关于身高的遗传研究在中国人身上进行，中国人是世界上最大的人口。本研究对中国385个核心家系共1,169个信息个体的成年身高进行了家族相关和分离分析。结果表明，中国人成人身高变异的17.2%由一对隐性主基因控制。身高的遗传度（± SE）为0.647（± 0.122）。本研究首次证明了中国人群成年身高的高度遗传决定性，为进一步定位和鉴定中国人群成年身高基因提供了有价值的参考。
Adult height (stature), as a complex quantitative trait, has been studied in different populations. However, few genetic studies on height were performed on the Chinese, the largest population in the world. In this study, familial correlation and segregation analyses were carried out for adult height in a Chinese sample composed of 385 nuclear families with a total of 1,169 informative individuals. The results suggest that a major gene with a recessive effect accounts for about 17.2% of the total adult height variation in the Chinese. Significant familial residual effects are found. The heritability (+/-SE) of height is estimated to be 0.647 (+/-0.122). This study, for the first time, provides evidence for the high degree of genetic determination of adult height in the Chinese population and furnishes a valuable reference for further mapping and identification of adult height genes in the Chinese.