A preliminary DTI study showing no brain structural change associated with adolescent cannabis use.
A preliminary DTI study showing no brain structural change associated with adolescent cannabis use.
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DOI：
10.1186/1477-7517-3-17
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发表时间：
2006-05-09
影响因子：
4.4
通讯作者：
Ardekani, Babak A
中科院分区：
文献类型：
--
作者：
Delisi, Lynn E;Bertisch, Hilary C;Ardekani, Babak A
对青少年时期经常使用大麻的个人（N = 10; 9名男性，1名女性，平均年龄21.1 +/- 2.9，范围：18-27）和从未使用大麻的年龄和性别匹配的年轻人（N = 10; 9名男性，1名女性，平均年龄23.0 +/- 4.4，范围：17-30）的脑MRI扫描进行分析。采用弥散张量成像（DTI）定量测定脑萎缩和白色物质完整性的表观弥散系数（ADC）和各向异性分数（FA）。还测量了全脑体积、侧脑室体积和杏仁核-海马复合体、上级颞回和整个颞叶（不包括杏仁核-海马复合体）的灰质体积。虽然组间存在差异，但未检测到与脑萎缩或白色物质完整性丧失证据一致的模式。它的结论是，经常使用大麻是不太可能是神经毒性的正常发育的青少年大脑。
Analyses were performed on brain MRI scans from individuals who were frequent cannabis users (N = 10; 9 males, 1 female, mean age 21.1 +/- 2.9, range: 18-27) in adolescence and similar age and sex matched young adults who never used cannabis (N = 10; 9 males, 1 female, mean age of 23.0 +/- 4.4, range: 17-30). Cerebral atrophy and white matter integrity were determined using diffusion tensor imaging (DTI) to quantify the apparent diffusion coefficient (ADC) and the fractional anisotropy (FA). Whole brain volumes, lateral ventricular volumes, and gray matter volumes of the amygdala-hippocampal complex, superior temporal gyrus, and entire temporal lobes (excluding the amygdala-hippocampal complex) were also measured. While differences existed between groups, no pattern consistent with evidence of cerebral atrophy or loss of white matter integrity was detected. It is concluded that frequent cannabis use is unlikely to be neurotoxic to the normal developing adolescent brain.