An Integrated Droplet Manipulation Platform with Photodeformable Microfluidic Channels
An Integrated Droplet Manipulation Platform with Photodeformable Microfluidic Channels
复制标题
具有光致变形微流体通道的集成液滴操纵平台
DOI：
10.1002/smtd.202100969
复制
发表时间：
2021-11-16
期刊：
影响因子：
12.4
通讯作者：
Yu, Yanlei
中科院分区：
文献类型：
--
作者：
Liu, Quan;Yu, Guodong;Yu, Yanlei
在微尺度上，微流控技术可以实现对微流体、液体输送、微机械等的精确控制，特别是在便携式分析系统的小型化方面，微流控技术具有重要的应用价值。在这里，通过结合拉普拉斯压力和毛细管冷凝来构建光致变形微流体平台，以在一个芯片中集成液体段塞的输送、融合、分离和混合。由于液晶聚合物的光致变形，产生拉普拉斯压力以推动段塞。毛细管冷凝是通过流体通道的精细设计引入的，允许在没有任何连接的微型阀的情况下熔融和分离段塞。该平台实现了催化氧化反应和蛋白质检测过程，适用于各种小型化生物医学应用，如便携式分析和床旁检测。
Manipulating droplets by light in microscale allows precise control of microfluidics, liquid delivery, micromachines, and so on. Among these applications, microfluidic technology is of particular interest for miniaturization of the portable analysis systems, which require the integration of various liquid operations in one device. Here, a photodeformable microfluidic platform is constructed by combining Laplace pressure and capillary condensation to integrate the transportation, fusion, separation, and mixing of liquid slugs in one chip. The Laplace pressure, attributed to the photodeformation of the liquid crystal polymers, is generated to propel the slug. The capillary condensation is introduced by the delicate design of the fluid channels, allowing the fusion and separation of slugs without any connected microvalves. Catalytic oxidation reaction and protein detection processes are realized in the platform, which are amenable to a variety of miniaturized bio‐medical applications, such as portable analysis and point of care testing.