Coronary angiography and intravascular ultrasound.
Coronary angiography and intravascular ultrasound.
复制标题
冠状动脉造影和血管内超声。
DOI：
10.1016/s0002-9149(01)01420-5
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
S. Nissen
中科院分区：
文献类型：
--
作者：
S. Nissen
长期以来，临床医生一直将管腔的大小和血管造影照片作为冠状动脉事件的预测指标。然而，心血管疾病不是管腔疾病，而是血管壁疾病。在早期阶段，动脉粥样硬化向外重塑外部弹性膜;只有在疾病过程的后期才会发生管腔狭窄，从而能够进行血管造影检测。这对药物治疗具有深远的意义，因为大约70%的患者出现急性心肌梗死（MI）或猝死，而不是心绞痛作为冠心病的首发症状。血管内超声（IVUS）可以提供动脉的详细图像，是目前唯一可用的技术，使医生能够常规可视化冠状动脉斑块。由于其在测量斑块体积和含量方面的敏感性，IVUS可能是一种有用的替代标记物，用于在比传统临床终点试验所需的更少数量的患者中评价动脉粥样硬化过程。
Clinicians have long used the size of the lumen and the angiogram as a predictor of coronary events. However, cardiovascular disease is not a disease of the lumen but a disease of the vessel wall. In early stages, atherosclerosis outwardly remodels the external elastic membrane; only late in the disease process does luminal narrowing occur, enabling angiographic detection. This has profound implications for drug therapy, because approximately 70% of patients present with acute myocardial infarction (MI) or sudden death, not angina as the first symptom of coronary disease. Intravascular ultrasound (IVUS) can provide detailed images of the artery and is the only technique currently available that enables physicians to routinely visualize coronary plaques. Due to its sensitivity in measuring plaque volume and content, IVUS may be a useful surrogate marker to evaluate the atherosclerotic process in smaller numbers of patients than required for conventional clinical endpoint trials.
影响因子：
37.8
作者：
LITTLE, WC;CONSTANTINESCU, M;SANTAMORE, WP
通讯作者：
SANTAMORE, WP