Different dynamic resting state fMRI patterns are linked to different frequencies of neural activity.
Different dynamic resting state fMRI patterns are linked to different frequencies of neural activity.
复制标题
DOI：
10.1152/jn.00235.2015
复制
发表时间：
2015-06
影响因子：
2.5
通讯作者：
G. Thompson;W. Pan;S. Keilholz
中科院分区：
文献类型：
--
作者：
G. Thompson;W. Pan;S. Keilholz
静息状态功能磁共振成像（rsfMRI）的结果表明，网络映射可以有助于理解行为和疾病，但很难将rsfMRI创建的映射转换为大脑中的神经电状态。最近，动态分析揭示了rsfMRI信号中的多种模式，这些模式与特定的神经活动带密切相关。为了进一步研究这些发现，同时记录的侵入性电生理和rsfMRI从大鼠被用来检查两种类型的电活动（直接测量的低频/次声活动和频带限制的功率较高的频率）和两种类型的动态rsfMRI（准周期模式或QPP，滑动窗口相关或SWC）。在大鼠的三种麻醉状态下测试神经活动和动态rsfMRI之间的关系：右美托咪定和高剂量和低剂量的异氟烷。在最轻麻醉剂右美托咪定下，次声电生理学与QPP相关，但与SWC无关，而高频带限功率与SWC相关，但与QPP无关。在异氟烷下的结果相似;然而，QPP也与带限功率相关，可能是由于麻醉剂诱导的爆发抑制状态。结果为这两种类型的动态rsfMRI与不同频率的神经活动有关的假设提供了额外的支持，但异氟烷麻醉可能使这种关系更加复杂。了解哪些神经频带在rsfMRI中表现为特定的动态模式，最终可能有助于分离出与精神分裂症和注意力缺陷障碍等疾病相关的rsfMRI信号成分。
Resting state functional magnetic resonance imaging (rsfMRI) results have indicated that network mapping can contribute to understanding behavior and disease, but it has been difficult to translate the maps created with rsfMRI to neuroelectrical states in the brain. Recently, dynamic analyses have revealed multiple patterns in the rsfMRI signal that are strongly associated with particular bands of neural activity. To further investigate these findings, simultaneously recorded invasive electrophysiology and rsfMRI from rats were used to examine two types of electrical activity (directly measured low-frequency/infraslow activity and band-limited power of higher frequencies) and two types of dynamic rsfMRI (quasi-periodic patterns or QPP, and sliding window correlation or SWC). The relationship between neural activity and dynamic rsfMRI was tested under three anesthetic states in rats: dexmedetomidine and high and low doses of isoflurane. Under dexmedetomidine, the lightest anesthetic, infraslow electrophysiology correlated with QPP but not SWC, whereas band-limited power in higher frequencies correlated with SWC but not QPP. Results were similar under isoflurane; however, the QPP was also correlated to band-limited power, possibly due to the burst-suppression state induced by the anesthetic agent. The results provide additional support for the hypothesis that the two types of dynamic rsfMRI are linked to different frequencies of neural activity, but isoflurane anesthesia may make this relationship more complicated. Understanding which neural frequency bands appear as particular dynamic patterns in rsfMRI may ultimately help isolate components of the rsfMRI signal that are of interest to disorders such as schizophrenia and attention deficit disorder.