Mast cell degranulation associated with sequestration and removal of Trichinella spiralis antigens.
Mast cell degranulation associated with sequestration and removal of Trichinella spiralis antigens.
复制标题
肥大细胞脱粒与旋毛虫抗原的隔离和去除相关。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
N. Morakote
中科院分区：
文献类型：
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作者：
D. Justus;N. Morakote
发现将旋毛虫幼虫抗原皮下注射到旋毛虫感染的小鼠体内后发生的肥大细胞脱颗粒与释放的颗粒的抗原结合以及吞噬细胞对颗粒抗原复合物的摄取有关。类似的活性可以在体外得到证明，此外，还发现活的完整肥大细胞瘤和腹膜肥大细胞迅速吸收荧光素标记的幼虫抗原并将其储存在其细胞质颗粒中，如颗粒周荧光所证明的那样。使用体外方法可以很容易地证明肝素和旋毛虫抗原以及其他相关和不相关的寄生虫抗原之间的复合物形成。这些观察结果强烈表明肥大细胞在寄生虫感染中发挥着显着且重要的支持作用。
Mast cell degranulation which occurred following the subcutaneous injection of trichinella larval antigen into trichinella-infected mice was found to be associated with antigen binding by the released granules and with the uptake of granule antigen complexes by phagocytic cells. Similar activity could be demonstrated in vitro, and in addition it was found that living intact mastocytoma and peritoneal mast cells rapidly took up fluorescein-labeled larval antigen and stored it in their cytoplasmic granules as evidenced by perigranular fluorescence. Complex formation between heparin and trichinella antigens as well as other related and unrelated parasitic antigens could readily be demonstrated using in vitro methods. These observations strongly suggest that mast cells play a significant and important supportive role in parasitic infections.