Precursor-Directed Biosynthesis of Curcumin Analogs in Escherichia coli
Precursor-Directed Biosynthesis of Curcumin Analogs in Escherichia coli
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DOI：
10.1271/bbb.90866
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发表时间：
2010-03-01
影响因子：
1.6
通讯作者：
Horinouchi, Sueharu
中科院分区：
文献类型：
--
作者：
Katsuyama, Yohei;Hirose, Yutaka;Horinouchi, Sueharu
姜黄素类化合物是姜黄根茎中的天然产物，具有多种生物活性，包括抗氧化和抗肿瘤活性。因此，姜黄素类化合物作为潜在的药物受到关注。外源性补充与各种羧酸盐前体基因工程大肠杆菌细胞进行人工组装的姜黄素类化合物的生物合成途径，导致17个非天然姜黄素类化合物的生产。
Curcuminoids, natural products in the rhizome of turmeric, show various biological activities, including antioxidant and antitumor activities. For this reason, curcuminoids have been focused on as potential pharmaceuticals. Exogenous supplementation with various carboxylate precursors in genetically engineered Escherichia coli cells carrying an artificially assembled pathway for curcuminoid biosynthesis led to the production of 17 unnatural curcuminoids.