sSema4D levels are increased in coronary heart disease and associated with the extent of coronary artery stenosis
sSema4D levels are increased in coronary heart disease and associated with the extent of coronary artery stenosis
复制标题
冠心病患者 sSema4D 水平升高，且与冠状动脉狭窄程度相关
DOI：
10.1016/j.lfs.2019.01.021
复制
发表时间：
2019-02-15
期刊：
影响因子：
6.1
通讯作者：
Zhang, Xiangyu
中科院分区：
文献类型：
--
作者：
Gong, Hui;Lyu, Xing;Zhang, Xiangyu
目的：探讨血清可溶性信号素4D(SSema4D)与冠心病(CHD)及冠状动脉狭窄程度的关系。128例确诊为冠心病，60例冠状动脉造影阴性作为对照。冠状动脉狭窄程度通过冠状动脉病变支数和Gensini评分系统进行评估。结果：冠心病患者血清sSema4D水平显著高于对照组(P<0.001)，急性冠脉综合征组显著高于稳定型心绞痛组(P<0.05)和对照组(P<0.05)。Gensini评分高的组血清sSema4D水平较高。血清sSema4D浓度与Gensini评分呈正相关(r=0.735，p<；0.001)，是唯一显著影响Gensini评分的独立因素(p<；0.001)。所有受试者血清sSema4D水平与C反应蛋白水平呈正相关(r=0.182，p=0.013)。SSema4D和CRP水平升高与CHD的存在独立相关。结论：CHD患者血清sSema4D水平升高，特别是在ACS患者。血清sSema4D可能是冠心病的独立危险因素，并在一定程度上反映冠状动脉狭窄程度。
Objective: The aim of this study was to evaluate the association between serum soluble semaphorin4D (sSema4D) and coronary heart disease (CHD) and the extent of coronary artery stenosis.Methods: The study included 188 cases that underwent coronary angiography because of precordial pain. One hundred and twenty-eight cases were diagnosed with CHD; 60 cases with negative coronary angiography served as controls. Coronary stenosis was evaluated by the number of diseased coronary artery and Gensini scoring system. Serum sSema4D and C-reactive protein (CRP) levels were measured.Results: Serum sSema4D levels in CHD patients were significantly higher than those of controls (p < 0.001) and the levels in those with acute coronary syndrome (ACS) were significantly higher than those with stable angina pectoris (p < 0.05) and controls (p < 0.05). Higher levels of serum sSema4D were observed in the group with high Gensini scores. Serum sSema4D concentration was positively correlated with the Gensini score (r = 0.735, p < 0.001) and was the only independent factor that significantly influenced the Gensini score (p < 0.001). Serum sSema4D levels were positively correlated with CRP levels in all subjects (r = 0.182, p = 0.013). Elevated sSema4D and CRP levels were independently associated with the presence of CHD.Conclusion: Serum sSema4D levels were increased in CHD patients, especially in those with ACS. Serum sSema4D may be an independent risk factor for CHD and reflect the extent of coronary artery stenosis to some extent.