Correlation of astrogliosis and substance P immunoreactivity in the brainstem of victims of sudden infant death syndrome.
Correlation of astrogliosis and substance P immunoreactivity in the brainstem of victims of sudden infant death syndrome.
复制标题
婴儿猝死综合症患者脑干中星形胶质细胞增生与 P 物质免疫反应性的相关性。
DOI：
10.1055/s-2008-1071539
复制
发表时间：
1993
期刊：
影响因子：
1.4
通讯作者：
Laurence E. Becker
中科院分区：
文献类型：
--
作者：
Hideo Yamanouchi;Sachio Takashima;Laurence E. Becker
P物质是一种定位于特定神经元的神经肽，其中一些可能参与呼吸调节。在缺氧条件下，脑干中P物质的含量增加。定量分析20例小岛屿发展中国家脑桥细胞对胶质纤维酸性蛋白和P物质的免疫反应性显示，与年龄匹配的对照组相比，网状结构和脑桥核中星形胶质细胞增生，三叉神经纤维中P物质增加。这些观察结果表明，小岛屿发展中国家星形胶质细胞附近的神经元可能发生了改变，P物质的表达明显增加，尽管这种变化对呼吸控制的功能意义尚不确定。
Substance P is a neuropeptide localized to selected neurons some of which may be involved in respiratory regulation. Substance P appears to be increased in the brainstem under conditions of hypoxia. A quantitative analysis of immunoreactivity to glial fibrillary acidic protein and substance P in the pons of 20 SIDS victims showed astroglial proliferation in the reticular formation and pontine nuclei and an increase of substance P in trigeminal fibers compared with age-matched controls. These observations suggest that in SIDS the neurons in the vicinity of the astrogliosis may be altered as indicated by the apparent increased expression of substance P, although the functional significance of this change on respiratory control is undetermined.