The LIM homeobox gene ceh-14 confers thermosensory function to the AFD neurons in Caenorhabditis elegans
The LIM homeobox gene ceh-14 confers thermosensory function to the AFD neurons in Caenorhabditis elegans
复制标题
DOI：
10.1016/s0896-6273(00)81062-4
复制
发表时间：
2000-03-01
期刊：
影响因子：
16.2
通讯作者：
Bürglin, TR
中科院分区：
文献类型：
--
作者：
Cassata, G;Kagoshima, H;Bürglin, TR
在秀丽隐杆线虫中，三对神经元AFD、AIY和AIZ在热感觉中起关键作用。LIM同源盒基因ceh-14在AFD热感觉神经元中表达。Ceh-14突变动物表现出趋热行为，尽管神经元仍然存在并分化。另外两个LIM同源盒基因ttx-3和lin-11分别在AIY和AIZ两个中间神经元中起作用。因此，三个关键的热感觉神经元是由三个不同的LIM同源盒基因指定的。Ceh-14 ttx-3 lin-11三重突变动物具有基本的嗜冷性热亲和性行为，表明存在第二种热亲和性途径。ceh-14在化学感觉神经元中的错误表达可以在不损害化学感觉功能的情况下恢复热致行为。因此，ceh-14赋予神经元热感觉功能。
In Caenorhabditis elegans three pairs of neurons, AFD, AIY, and AIZ, play a key role in thermosensation. The LIM homeobox gene ceh-14 is expressed in the AFD thermosensory neurons. ceh-14 mutant animals display athermotactic behaviors, although the neurons are still present and differentiated. Two other LIM homeobox genes, ttx-3 and lin-11, function in the two interneurons AIY and AIZ, respectively. Thus, the three key thermosensory neurons are specified by three different LIM homeobox genes. ceh-14 ttx-3 lin-11 triple mutant animals have a basic cryophilic thermotaxis behavior indicative of a second thermotaxis pathway. Misexpression of ceh-14 in chemosensory neurons can restore thermotactic behavior without impairing the chemosensory function. Thus, ceh-14 confers thermosensory function to neurons.