Efficacy and safety of photodynamic therapy with temoporfin in curative treatment of recurrent carcinoma of the oral cavity and oropharynx
Efficacy and safety of photodynamic therapy with temoporfin in curative treatment of recurrent carcinoma of the oral cavity and oropharynx
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DOI：
10.1007/s00405-012-2083-7
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发表时间：
2013-03-01
影响因子：
2.6
通讯作者：
Ceruse, P.
中科院分区：
文献类型：
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作者：
Durbec, M.;Cosmidis, A.;Ceruse, P.
上消化道复发癌的治疗选择有限。这些肿瘤的预后仍然很差，复发率很高，中位生存时间较短。光动力疗法（PDT）是一种相对较新的治疗方法，其结合使用光敏剂和光来诱导对组织的细胞毒性作用。这是一项回顾性单中心研究，在口腔癌或口咽癌复发或既往照射区域再次出现肿瘤的患者中进行。无淋巴结或其他器官转移。在替莫泊芬（Foscan（A（R）注射后96小时进行激光治疗。在我们的系列中，我们有14例完全缓解，1例部分缓解。1年总生存率为72%，5年为36%。1年疾病特异性生存率为82%，5年为45%。1年无复发生存率为52%，5年为34%。主要描述的副作用是照明区域的疼痛，控制良好。PDT与Foscan（A（R））在生存率和生活质量改善方面提供了有用的结果，几乎没有不良事件或严重并发症。事实上，它具有低毒性和治疗过程可以重复意味着它应该考虑在治疗复发性UADT癌的医疗设备。
Therapeutic options for recurrent carcinoma of the upper a,rodigestive tract (UADT) are limited. The prognosis of these tumours remains poor with significant rate of recurrence and a lower median survival time. Photodynamic therapy (PDT) is a relatively new therapeutic alternative which combines the use of a photosensitising agent and light to induce a cytotoxic effect on the tissues. This is a retrospective single-centre study carried out in patients with a recurrence of an oral cavity or oropharyngeal carcinoma or a second appearance of tumour in a previously irradiated area. There were no metastases in lymph nodes or other organs. Laser treatment was carried out 96 h after temoporfin (Foscan(A (R))) injection. In our series we had 14 cases with a complete response, 1 partial response. Overall survival at 1 year was 72 % and 36 % at 5 years. Disease-specific survival at 1 year was 82 % and 45 % at 5 years. Recurrence-free survival at 1 year was 52 % and 34 % at 5 years. Side effects mainly described are pain in the area of illumination, well controlled. PDT with Foscan(A (R)) gives useful results in terms of survival and improvement in quality of life with few adverse events or severe complications. The fact that it has low toxicity and that treatment sessions can be repeated mean it should be considered in the therapeutic armamentarium for recurrent carcinoma of the UADT.