Spirometric assessment of emphysema presence and severity as measured by quantitative CT and CT-based radiomics in COPD
Spirometric assessment of emphysema presence and severity as measured by quantitative CT and CT-based radiomics in COPD
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DOI：
10.1186/s12931-019-1049-3
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发表时间：
2019-05-23
影响因子：
5.8
通讯作者：
Pistolesi, Massimo
中科院分区：
文献类型：
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作者：
Occhipinti, Mariaelena;Paoletti, Matteo;Pistolesi, Massimo
背景：COPD中气流阻塞的机制不能通过标准肺活量测定来区分。我们确定气道生物力学特性的数学模型，如肺活量测定，是否可以提供肺气肿存在和严重程度的估计，如通过计算机断层扫描（CT）指标和基于CT的放射组学量化。方法采用标准CT指标（VIDA）和吸气-呼气CT共登记分析（ImbioLDA）对194例COPD患者进行肺功能检查，量化肺气肿的存在和严重程度。根据低于-950霍斯菲尔德单位的低衰减面积百分比（%LAA(-950insp)）将患者分类为无肺气肿（NE）， LAA % （-950insp）。
BackgroundThe mechanisms underlying airflow obstruction in COPD cannot be distinguished by standard spirometry. We ascertain whether mathematical modeling of airway biomechanical properties, as assessed from spirometry, could provide estimates of emphysema presence and severity, as quantified by computed tomography (CT) metrics and CT-based radiomics.MethodsWe quantified presence and severity of emphysema by standard CT metrics (VIDA) and co-registration analysis (ImbioLDA) of inspiratory-expiratory CT in 194 COPD patients who underwent pulmonary function testing. According to percentages of low attenuation area below -950 Hounsfield Units (%LAA(-950insp)) patients were classified as having no emphysema (NE) with %LAA(-950insp)