Study of Factors Influencing Dry Eye in Rheumatoid Arthritis
Study of Factors Influencing Dry Eye in Rheumatoid Arthritis
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类风湿关节炎干眼影响因素的研究
DOI：
10.1155/2020/5768679
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发表时间：
2020-08-08
影响因子：
1.9
通讯作者：
Li, Cheng
中科院分区：
文献类型：
--
作者：
Ma, Weifang;Wang, Guoliang;Li, Cheng
目的探讨类风湿关节炎（RA）患者干眼症与疾病活动性的关系。方法根据眼表疾病指数（OSDI）将RA患者分为有症状组（≥ 12分）和无症状组（< 12分）。采用疾病活动性评分（DAS-28）问卷将患者分为活动组（评分> 2.6）和稳定组（评分≤ 2.6）。对照组为20例年龄、性别相匹配的健康成人。对RA患者和健康成人进行泪膜破裂时间（TBUT）、泪半月板高度（TMH）、角膜荧光素染色（CFS）、睑板腺扫描（MS）、睑板腺分泌物评分（MSS）和眼睑边缘评估（EMS）检查。结果RA组TBUT明显低于对照组，CFS、MS、EMS、MSS明显高于对照组。有症状组TBUT明显低于无症状组，CFS明显高于无症状组。活动期RA组仅CFS高于稳定期RA组，其他指标两组间差异无统计学意义。RA病程与干眼症无明显相关性（P > 0.05）。结论类风湿活动并不一定导致干眼症加重。无论持续时间如何，RA与干眼症的严重程度没有关系。翻译的相关性。RA患者在疾病活动期存在干眼症是不容忽视的，因为干眼症患者往往缺乏症状和体征。
Purpose The present study investigated the relationship between dry eye and the disease activity in patients with rheumatoid arthritis (RA). Methods Patients with RA were divided by the Ocular Surface Disease Index (OSDI) into the symptomatic group (score ≥ 12) and the asymptomatic group (score < 12). By using the Disease Activity Score (DAS-28) questionnaire, they were divided into the active group (score > 2.6) and the stable group (score ≤ 2.6). In the control group, 20 healthy adults with matched sex and age were selected. RA patients and healthy adults were inspected for the tear film break time (TBUT), tear meniscus height (TMH), corneal fluorescein staining (CFS), meibomian scan (MS), meibomian gland secretion score (MSS), and eyelid margin assessment (EMS). Results The TBUT of the RA group was significantly less than that of the control group, while the CFS, MS, EMS, and MSS were higher. The TBUT of the symptomatic RA group was significantly less than that of the asymptomatic group, and the CFS was higher. In the active RA group, only the CFS was higher than that of the stable group, and there was no significant difference between the two groups for other parameters. Furthermore, there was no significant correlation between the course of RA and the dry eye (P > 0.05). Conclusion The rheumatoid activity does not necessarily lead to an aggravation of dry eye. Regardless of the duration, RA was not found to exhibit relation with the severity of dry eye. Translational Relevance. RA patients with disease active period cannot be ignored for the existence of dry eye, since patients with dry eye often lack the signs and symptoms.