Molecular genetics of familial renal cell carcinoma syndromes
Molecular genetics of familial renal cell carcinoma syndromes
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DOI：
10.1016/j.cll.2005.01.003
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发表时间：
2005-06-01
影响因子：
1.7
通讯作者：
Zhou, M
中科院分区：
文献类型：
--
作者：
Cohen, D;Zhou, M
肾细胞癌（RCC）是一组临床和遗传多样性疾病。家族性肾细胞癌综合征，虽然罕见，提供了一个宝贵的模型来研究肾癌发生的分子机制。许多癌基因和肿瘤抑制基因已被确定为负责几种形式的家族性RCC综合征。了解这些基因的分子通路将对家族性和散发性RCC的诊断和治疗产生重要影响。
Renal cell carcinoma (RCC) represents a group of clinically and genetically diverse diseases. Familial RCC syndromes, although rare, provide an invaluable model to study the molecular mechanisms of renal carcinogenesis. Many oncogenes, and tumor suppressor genes have been identified as responsible for several forms of familial RCC syndromes. Understanding of the molecular pathways of these genes will have significant impact on the diagnosis and treatment of familial and sporadic RCCs.