Serum levels of complement C4 fragments correlate with disease activity in multiple sclerosis: Proteomic analysis
Serum levels of complement C4 fragments correlate with disease activity in multiple sclerosis: Proteomic analysis
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DOI：
10.1016/j.jneuroim.2009.10.019
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发表时间：
2010-01-25
影响因子：
3.3
通讯作者：
Nomura, Fumio
中科院分区：
文献类型：
--
作者：
Sawai, Setsu;Umemura, Hiroshi;Nomura, Fumio
检测与复发-缓解型多发性硬化症（MS）疾病活动性相关的血清生物标志物。采用基质辅助激光解吸/电离飞行时间质谱法对MS患者和正常人的血清低分子肽谱进行了全面研究。患者在临床复发时血清1741 Da肽水平高于正常对照，并在缓解期间恢复正常。串联质谱分析表明，该肽是补体C4 （NGFKSHALQLNNRQI）的一个片段。该片段肽可能是疾病活动性的一个可能标志。这可能反映了补体激活在ms发病机制中的作用(C) 2009 Elsevier B.V.版权所有。
To detect serum biomarkers associated with disease activity in relapsing-remitting multiple sclerosis (MS). We Studied serum low-molecular peptide profiling of MS patients and normal controls comprehensively by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Serum level of 1741 Da peptide was increased at the time of clinical relapse in patients than in normal controls and returned toward normal during remission. Tandem mass spectrometry analysis revealed that the peptide was a fragment of complement C4 (NGFKSHALQLNNRQI). This fragment peptide could be a possible marker of disease activity. It may reflect complement activation in the pathogenesis of MS. (C) 2009 Elsevier B.V. All rights reserved.