Effects of intramedullary nails composed of a new β-type Ti-Nb-Sn alloy with low Young's modulus on fracture healing in mouse tibiae
Effects of intramedullary nails composed of a new β-type Ti-Nb-Sn alloy with low Young's modulus on fracture healing in mouse tibiae
复制标题
DOI：
10.1002/jbm.b.34064
复制
发表时间：
2018-11-01
影响因子：
3.4
通讯作者：
Itoi, Eiji
中科院分区：
文献类型：
--
作者：
Fujisawa, Hirokazu;Mori, Yu;Itoi, Eiji
材料杨氏模量对骨折愈合过程的影响尚不清楚。本研究旨在评估由低杨氏模量材料组成的髓内钉对骨折修复的影响。我们以前开发了一种低杨氏模量的钛铌锡合金接近人类皮质骨。本文通过热处理制备了杨氏模量分别为45和78 GPa的Ti-Nb-Sn合金，并比较了它们对骨折愈合的影响。在C57 BL/6小鼠的右胫骨中进行骨折和钉固定。通过显微计算机断层扫描（micro-CT）、组织形态计量学和RT-PCR评价骨愈合过程。在显微CT分析中，我们发现与78 GPa Ti-Nb-Sn合金相比，45 GPa Ti-Nb-Sn合金处理的小鼠骨折骨痂的骨体积更大。这在第14天用组织学证实，与78-GPa Ti-Nb-Sn组相比，45-GPa Ti-Nb-Sn组的新骨形成和软骨吸收加速。在第10天，45-GPa Ti-Nb-Sn组中的Acp 5表达低于78-GPa Ti-Nb-Sn组。这些结果表明，髓内钉固定具有较低的杨氏模量提供了更大的骨折修复能力。我们的45-GPa Ti-Nb-Sn合金是一种很有前途的骨折治疗植入物材料。(c)2018年威利期刊公司J Biomed Mater Res Part B：Appl Biomater，106 B：2841-2848，2018。
The influence of Young's moduli of materials on the fracture healing process remains unclear. This study aimed to assess the effects of intramedullary nails composed of materials with low Young's moduli on fracture repair. We previously developed a -type Ti-Nb-Sn alloy with low Young's modulus close to that of human cortical bone. Here, we prepared two Ti-Nb-Sn alloys with Young's moduli of 45 and 78 GPa by heat treatment, and compared their effects on fracture healing. Fracture and nailing were performed in the right tibiae of C57BL/6 mice. The bone healing process was evaluated by microcomputed tomography (micro-CT), histomorphometry, and RT-PCR. We found larger bone volumes of fracture callus in the mice treated with the 45-GPa Ti-Nb-Sn alloy as compared with the 78-GPa Ti-Nb-Sn alloy in micro-CT analyses. This was confirmed with histology at day 14, with accelerated new bone formation and cartilage absorption in the 45-GPa Ti-Nb-Sn group compared with the 78-GPa Ti-Nb-Sn group. Acp5 expression was lower in the 45-GPa Ti-Nb-Sn group than in the 78-GPa Ti-Nb-Sn group at day 10. These findings indicate that intramedullary fixation with nails with a lower Young's modulus offer a greater capacity for fracture repair. Our 45-GPa Ti-Nb-Sn alloy is a promising material for fracture treatment implants. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2841-2848, 2018.