Bone mineral density and its relationship with body mass index in postmenopausal women with type 2 diabetes mellitus in mainland China
Bone mineral density and its relationship with body mass index in postmenopausal women with type 2 diabetes mellitus in mainland China
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DOI：
10.1007/s00774-008-0023-9
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发表时间：
2009-01
影响因子：
3.3
通讯作者：
P. Shan;Xian‐ping Wu;Hong Zhang;Xing-zhi Cao;W. Gu;X. Deng;Chi Gu;E. Liao
中科院分区：
文献类型：
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作者：
P. Shan;Xian‐ping Wu;Hong Zhang;Xing-zhi Cao;W. Gu;X. Deng;Chi Gu;E. Liao
中国大陆绝经后2型糖尿病（T2 DM）妇女的骨密度（BMD）及其与体重指数（BMI）的关系尚不明确。本研究旨在评估这种关联，包括1，042例绝经后T2 DM女性和919例非糖尿病对照受试者。采用双能X线骨密度仪测量后前脊柱和左髋的骨密度。根据BMI将糖尿病患者分为低BMI组（DML < 18.5 kg/m2）、中等BMI组（DMM 18.5-24.9 kg/m2）和高BMI组（DMH ≥ 25 kg/m2）。糖尿病患者组间BMD值存在明显的梯度差异，DML < DMM < DMH。在拟合曲线上，各骨区BMD随年龄变化，DML的BMD比DMM的BMD低约15%，DMM的BMD比DMH的BMD低约10%。对于骨质疏松症的患病率和风险，在糖尿病组中观察到梯度差异，DML > DMM对照组> DMH。髋关节骨质疏松风险高于腰椎，尤其是在DML中。该研究表明，绝经后T2 DM女性腰椎BMD较高，骨质疏松风险较低，BMI较低是中国大陆骨质疏松的一个指标。
Bone mineral density (BMD) and its association with body mass index (BMI) are uncertain in postmenopausal women with type 2 diabetes mellitus (T2DM) in mainland China. This study was performed to assess this association including 1,042 postmenopausal women with T2DM and 919 non-diabetic control subjects. Bone mineral density of the posteroanterior spine and of the left hip was measured by use of dual-energy X-ray absorptiometry. Diabetic participants were divided into three groups according to BMI, i.e. low BMI (DML < 18.5 kg/m2), intermediate BMI (DMM 18.5–24.9 kg/m2), and high BMI (DMH ≥ 25 kg/m2). The BMD values of diabetic subjects between groups exhibited a significant gradient difference, with DML < DMM < DMH. On the fitting curves, where BMD in various skeletal regions varied with age, BMDs of DML were approximately 15% lower than those of DMM, and those of DMM were approximately 10% lower than those of DMH. For prevalence and risks of osteoporosis a gradient difference was observed among diabetic groups, DML > DMM ≈ control > DMH. The osteoporosis risk was higher for the hip than for the lumbar spine, especially in DML. This study indicated that postmenopausal women with T2DM had higher BMD and lower osteoporosis risk in the lumbar spine, and that lower BMI was an indicator of osteoporosis in mainland China.