Diffusion of Anisotropic Colloidal Microparticles Fabricated Using Two‐Photon Lithography
Diffusion of Anisotropic Colloidal Microparticles Fabricated Using Two‐Photon Lithography
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DOI：
10.1002/ppsc.202100033
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发表时间：
2021-07
影响因子：
2.7
通讯作者：
David Doan;John Kulikowski;X. Gu
中科院分区：
文献类型：
--
作者：
David Doan;John Kulikowski;X. Gu
具有复杂形状的聚合物颗粒是生物医学治疗、胶体自组装和微型机器人所必需的。利用现有方法合成具有高结构精度的简单形状（如球体、立方体）以外的粒子一直是一项挑战。本文报道了一种利用双光子光刻技术制造复杂3D形状聚合物微粒的方法，并将微粒分散在玻璃基板上的水溶液中。演示了多面体（例如，四面体，金字塔），多面体（例如，四足体，六足体）和其他尺寸为5-10微米的形状的制造。共聚焦显微镜用于跟踪球体、四面体、四足体和螺旋形粒子在衬底附近的运动，并确定它们的平移扩散系数。HYDRO++用于模拟颗粒远离基材的运动。确定了颗粒尺寸和衬底对球形颗粒扩散的影响，发现与球形颗粒相比，非球形颗粒在衬底处的阻力增加。
Polymeric particles with complex shapes are required for biomedical therapies, colloidal self‐assembly, and micro‐robotics. It has been challenging to synthesize particles beyond simple shapes (e.g., spheres, cubes) with high structural accuracy using existing methods. Here, a method for fabricating polymeric microparticles of complex 3D shapes is reported using two‐photon lithography, and dispersing the particles in an aqueous solution on a glass substrate. The fabrication of polyhedrons (e.g., tetrahedron, pyramid), polypods (e.g., tetrapod, hexapod), and other shapes of 5–10 µm in size is demonstrated. Confocal microscopy is used to track the motion of the sphere, tetrahedron, tetrapod, and screw‐shaped particles near the substrate, and determine their translational diffusion coefficients. HYDRO++ is used to simulate the motion of the particles far from the substrate. The influence of particle size and substrate effects on diffusion in the spherical particles is determined and finds that the non‐spherical particles have increased hindrance at the substrate compared to the spherical particles.