Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues.

Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues.
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DOI:
10.1186/gb-2008-9-9-r139
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发表时间:
2008
期刊:
影响因子:
12.3
通讯作者:
Kallioniemi, Olli
Kallioniemi, Olli
中科院分区:
生物学1区
文献类型:
--
作者:
Kilpinen, Sami;Autio, Reija;Ojala, Kalle;Iljin, Kristiina;Bucher, Elmar;Sara, Henri;Pisto, Tommi;Saarela, Matti;Skotheim, Rolf I.;Bjorkman, Mari;Mpindi, John-Patrick;Haapa-Paananen, Saija;Vainio, Paula;Edgren, Henrik;Wolf, Maija;Astola, Jaakko;Nees, Matthias;Hautaniemi, Sampsa;Kallioniemi, Olli

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本文提出了一种通过基因表达阵列实验比较大多数人类基因mRNA表达水平的方法,并建立了结果数据库。我们对人类基因的组织和疾病特异性功能的了解相当有限,而且高度具体。在这里,我们开发了一种方法,用于比较大多数人类基因的mRNA表达水平,通过9783 Affymetrix基因表达阵列实验,代表43种正常人类组织类型,68种癌症类型和64种其他疾病。这个正常人体组织和病理条件下的基因表达模式数据库涵盖1.13亿个数据点,可从GeneSapiens网站获得。
A method for the comparison of mRNA expression levels of most human genes across gene expression array experiments, and a database of the results, are presented. Our knowledge on tissue- and disease-specific functions of human genes is rather limited and highly context-specific. Here, we have developed a method for the comparison of mRNA expression levels of most human genes across 9,783 Affymetrix gene expression array experiments representing 43 normal human tissue types, 68 cancer types, and 64 other diseases. This database of gene expression patterns in normal human tissues and pathological conditions covers 113 million datapoints and is available from the GeneSapiens website.
DOI: 10.1158/0008-5472.can-06-1986
发表时间: 2006-11-01
期刊: CANCER RESEARCH
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