Dynamic statistical parametric mapping for analyzing the magnetoencephalographic epileptiform activity in patients with epilepsy
Dynamic statistical parametric mapping for analyzing the magnetoencephalographic epileptiform activity in patients with epilepsy
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DOI：
10.1177/08830738050200041601
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发表时间：
2005-04-01
影响因子：
1.9
通讯作者：
Halgren, E
中科院分区：
文献类型：
--
作者：
Shiraishi, H;Stufflebeam, SM;Halgren, E
我们目前的目的是评估动态统计参数映射的适用性，动态统计参数映射是一种定位癫痫患者脑磁图记录的癫痫样活动的新方法。我们报告四名小儿局灶性癫痫患者。采用306通道全头头盔型传感器阵列采集脑磁图数据。我们计算了等效电流偶极子和间隔期癫痫状放电的动态统计参数映射电影，这些电影基于最小l2范数估计，最小化偶极子元素振幅的平方和。癫痫样间期放电的动态统计参数映射分析可以显示癫痫样间期放电的快速变化和传播。根据这些发现，可以发现特异性的癫痫性病变-局灶性皮质发育不良，并成功进行手术治疗。应用动态统计参数映射对可能存在潜在局灶性皮质发育不良的患者进行间歇癫痫样放电的术前分析似乎很有希望，并可能有助于指导侵入性电极的放置。
Our current purpose is to evaluate the applicability of dynamic statistical parametric mapping, a novel method for localizing epileptiform activity recorded with magnetoencephalography in patients with epilepsy. We report four pediatric patients with focal epilepsies. Magnetoencephalographic data were collected with a 306-channel whole-head helmet-shaped sensor array. We calculated equivalent current dipoles and dynamic statistical parametric mapping movies of the interictal epileptiform discharges that were based in the minimum-L2 norm estimate, minimizing the square sum of the dipole element amplitudes. The dynamic statistical parametric mapping analysis of interictal epileptiform discharges can demonstrate the rapid change and propagation of interical epileptiform discharges. According to these findings, specific epileptogenic lesion-focal cortical dysplasia could be found and patients could be operated on successfully. The presurgical analysis of interictal epileptiform discharges using dynamic statistical parametric mapping seems to be promising in patients with a possible underlying focal cortical dysplasia and might help to guide the placement of invasive electrodes.