Myeloperoxydase activity in the pathogenesis of cholesteatoma
Myeloperoxydase activity in the pathogenesis of cholesteatoma
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DOI：
10.1007/s12070-010-0011-y
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发表时间：
2010-06
影响因子：
0.6
通讯作者：
Ö. Çelebi;M. Paksoy;S. Aydın;A. Şanlı;Ömer Taşdemir;A. Gül
中科院分区：
文献类型：
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作者：
Ö. Çelebi;M. Paksoy;S. Aydın;A. Şanlı;Ömer Taşdemir;A. Gül
目的：应用免疫组化方法检测髓过氧化物酶（MPO）在慢性中耳炎（COM）伴中耳乳突瘤患者骨破坏中的作用，探讨髓过氧化物酶（MPO）活性与COM伴中耳乳突瘤患者骨破坏的关系。患者组”和30例因中耳炎手术的患者被纳入“对照组”。MPO阳性监测时，一个细胞质染色过程performed. ResultsWhile，一个显着的差异是目前在统计学上先进的水平组之间的MPO水平（p = 0.001; p < 0.01）。然而，MPO活性在包括在对照组中的患者中不存在或可以在非常轻微的水平上观察到。在入组研究组的患者中可观察到中等水平或强烈水平的活动。除硬脑膜破坏外，与中耳、乳突腔侵蚀及髓过氧化物酶活性有关的所有发现均具有统计学意义（p < 0.05）。根据硬脑膜骨壁的破坏程度，MPO活性的分布差异无统计学意义（p > 0.05）。当术前确定MPO水平并获得与骨质侵蚀相关的足够信息时，可能会打开一个新的时代，在治疗胆脂瘤。
ObjectiveThe aim of this study was to determine the effect of myeloperoxydase (MPO) in bone destruction in patients of chronic otitis media (COM) with cholesteatoma by immtino-histochemical staining and to conclude the possible relationship between bone destruction in patients with cholesteatoma accompanied with COM and MPO activity.MethodsThe study was conducted on a total number of 81 patients where 51 of the patients were enrolled in the “patient group” and 30 of the patients were enrolled in the “control group” whom were operated due to otitis media. MPO positivism was monitored when a cytoplasmic staining process was performed.ResultsMeanwhile, a significant difference is present at a statistically advanced level between the MPO levels of groups (p = 0.001; p < 0.01). However, MPO activity is absent in patients included in the control group or it can be observed at a very slight level. A moderate level or intense level of activity can be observed in patients enrolled in the study group. Excluding the destruction at the dura, all findings related with the middle ear and the erosion of the mastoid cavity and MPO activity indicated a statistically significant difference (p < 0.05). According to the destruction at the wall of the dura bone, distribution of MPO activity did not display a statistically meaningful difference (p > 0.05).ConclusionIn this study, we investigated the relationship between MPO level and bone destruction and found a significant level of correlation among the fore said. A new era may be opened in the treatment of cholesteatoma when preoperative MPO levels are determined and adequate information is obtained related with bone erosion.