Amphotericin B Lipid Complex (Ablc™): A Molecular Rationale for the Attenuation of Amphotericin B Related Toxicities
Amphotericin B Lipid Complex (Ablc™): A Molecular Rationale for the Attenuation of Amphotericin B Related Toxicities
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两性霉素 B 脂质复合物 (Ablc™)：减弱两性霉素 B 相关毒性的分子原理
DOI：
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
C. Swenson
中科院分区：
文献类型：
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作者：
A. Janoff;W. Perkins;S. Saletan;C. Swenson
尽管有相关的毒性，但阿替霉素B仍然是治疗各种系统性真菌感染的首选药物，这些真菌感染在其引入之前总是致命的。作为链霉菌的天然产物，该化合物的结构相当引人注目：其长度约为磷脂分子，但沿着其长轴具有多羟基和多烯烃主链。这些相反极性的结构域赋予了阿替霉素不寻常的溶解度特性，似乎是其通过膜扰动和跨膜离子梯度耗尽破坏细胞的关键，多年来吸引了大量对药物-脂质相互作用感兴趣的物理化学家的注意。已广泛研究了阿朴霉素与脂质体膜的结合，并与脂质组成、曲率半径、物理状态、存在的甾醇的量和类型以及我们手中的药物/脂质比相关（1）。
AbstractDespite its associated toxicities, amphotericin B remains the drug of first choice for a variety of systemic fungal infections that were invariably fatal prior to its introduction. A natural product of Streptomyces, the structure of this compound is quite remarkable: it is approximately the length of a phospholipid molecule but possesses along its long axis both a polyhydroxyl and polyene hydrocarbon backbone. These domains of opposite polarity imbue amphotericin with unusual solubility properties, appear to be the key to its destruction of cells via membrane perturbation and depletion of transmembrane ion gradients, and have attracted, over the years, the attentions of a plethora of physical chemists interested in drug-lipid interactions. The association of amphotericin with liposome membranes has been studied extensively and has been related to lipid composition, radius of curvature, physical state, the amount and type of sterol present, and in our hands, drug/lipid ratios (1).
含有两性霉素 B 的聚合磷脂囊泡：体外毒性和抗真菌活性评价。
影响因子：
3.8
作者：
Mehta,R;Hsu,MJ;Juliano,RL;Krause,HJ;Regen,SL
通讯作者：
Regen,SL