Implantation of the undulation pump total artificial heart in the goat.
Implantation of the undulation pump total artificial heart in the goat.
复制标题
波动泵全人工心脏植入山羊体内。
DOI：
10.1046/j.1525-1594.1999.06033.x
复制
发表时间：
1999
影响因子：
2.4
通讯作者：
K. Imachi
中科院分区：
文献类型：
--
作者：
Y. Abe;T. Chinzei;T. Ono;S. Mochizuki;I. Saito;P. Guba;T. Karita;Y. P. Sun;A. Kouno;T. Isoyama;K. Baba;K. Imachi
利用小型连续流动置换式血泵（波动泵）研制了波动泵型全人工心脏（UPTAH）。为了澄清和改善胸部植入所伴随的问题，在体重41.3-79.2 kg的山羊上进行了14次动物实验。UPTAH可以植入所有山羊的胸部，并以调制脉动模式驱动。第一个问题是心房抽吸效应。通过发展软盘和改进心房袖带，可在一定程度上预防这一问题。还尝试了心房抽吸效应的自动检测和释放。下一个问题是急性肺水肿，伴随着动物的姿势变化。左心房压力自动控制的发展可以防止这个问题。下一个问题是，密封膜上的一个小孔会有少量血液泄漏。膜的制造过程的改进防止了这种情况。有了这些改进，这种独特的植入式全人工心脏可以获得10天的生存期。
The undulation pump total artificial heart (UPTAH) was developed by using small-size continuous-flow displacement-type blood pumps (undulation pump). To clarify and improve the problems accompanied by the implantation in the chest, 14 animal experiments were performed on goats weighing 41.3-79.2 kg. The UPTAH could be implanted in the chest of all goats and was driven with a modulation pulsatile mode. The first problem was the atrial suction effect. This problem could be prevented to some extent by developing the soft disk and by improving atrial cuffs. An automatic detection and releasing of the atrial suction effect was also tried. The next problem was acute lung edema accompanied by the postural change of the animal. Development of the automatic control of left atrial pressure could prevent this problem. Small blood leakage from a pinpoint hole in the seal membrane was the next problem. Improvement of the manufacturing procedure of the membrane prevented this. With these improvements, a 10 day survival could be obtained with this unique implantable total artificial heart.