The prevalence of parasite infestation and house dust mite sensitization in Gabonese schoolchildren
The prevalence of parasite infestation and house dust mite sensitization in Gabonese schoolchildren
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DOI：
10.1159/000049519
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发表时间：
2001-11-01
影响因子：
2.8
通讯作者：
Yazdanbakhsh, M
中科院分区：
文献类型：
--
作者：
van den Biggelaar, AHJ;Lopuhaa, C;Yazdanbakhsh, M
背景：在寄生虫感染高度流行的世界欠发达地区，过敏性疾病似乎不太流行。总的来说，关于组织和血液寄生寄生虫的慢性感染与特应性之间的关系所知不多。方法：在加蓬某血液和组织寄生虫流行地区，对520名学龄儿童进行寄生虫学检查和皮肤刺检，检查一组常见的环境空气过敏原。检测过敏原特异性IgE和多克隆IgE水平。结果：学童中血吸虫和丝虫病感染随年龄增长而增加，而疟疾在低龄儿童中更为普遍。与过敏原致敏性随年龄增长而增加相反，皮肤试验反应性倾向于下降。具有螨特异性IgE抗体的儿童人数（47%）远远超过皮肤点刺试验（11%）。螨致敏性在感染血吸虫和/或丝虫病的儿童中最高，而皮肤试验反应性最低。多重逻辑回归显示，皮肤试验阳性的风险随着螨特异性IgE水平的增加而增加8倍，但当感染血期蠕虫时，风险降低了72%。结论：慢性血液和组织寄生虫感染通常能够调节宿主的免疫反应，与致敏人群的皮肤试验反应性呈负相关。版权所有(C) 2001 S. Karger AG，巴塞尔
Background: Allergic diseases seem less prevalent in communities in less developed parts of the world, where parasite infections are highly prevalent. Altogether not much is known about the association between chronic infections with tissue and blood-dwelling parasites and atopy. Methods: In an area in Gabon endemic for blood and tissue parasites, 520 schoolchildren were parasitologically examined and skin prick-tested for a set of common environmental aeroallergens. Levels of allergen-specific IgE and polyclonal IgE were measured. Results: In schoolchildren schistosome and filarial infections increased with age, whereas malaria was more prevalent in younger children. In contrast to allergen sensitization that increased with age, skin test reactivity tended to decline. The number of children with mite-specific IgE antibodies (47%) by far exceeded the number responding to skin prick testing (11%). Mite sensitization was found to be the highest in children infected with schistosomes and/or filariae whereas skin test reactivity was lowest. The multiple logistic regression showed that the risk of a positive skin test was 8-fold higher with increasing levels of mite-specific IgE but was reduced by 72% when infected with blood stage helminths. Conclusions: Chronic blood and tissue parasite infections that are often capable of modulating immune responses in the host are negatively associated with skin test reactivity in a sensitized population. Copyright (C) 2001 S. Karger AG, Basel.