A metamorphosis distance for embryonic cardiac action potential interpolation and classification.
A metamorphosis distance for embryonic cardiac action potential interpolation and classification.
复制标题
用于胚胎心脏动作电位插值和分类的变态距离。
DOI：
10.1007/978-3-642-40811-3_59
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Vidal,René
中科院分区：
文献类型：
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作者：
Gorospe,Giann;Younes,Laurent;Tung,Leslie;Vidal,René
人类胚胎干细胞心肌细胞（hESC-CMs）在组织移植和修复中的应用导致了心脏再生医学的重大进展。然而，为了避免潜在的心律失常，用于替代治疗的hESC-CM必须与成人心房、心室和结表型电生理相容。目前用于对hESC-CM的电生理学进行分类的方法主要依赖于细胞的动作电位（AP）的形状，每个专家主观地决定它是类神经节、类心房还是类心室。然而，分类是困难的，因为hESC-CM的AP的形状可能与成熟细胞的形状不一致。在本文中，我们建议使用ametamorphosis distance来比较hESC-CMs和成体细胞模型的AP。这涉及构建对应于成熟过程的不同阶段的AP家族，并测量AP之间的变形量。实验结果表明，该距离具有较好的插值效果和分类效果.
The use of human embryonic stem cell cardiomyocytes (hESC-CMs) in tissue transplantation and repair has led to major recent advances in cardiac regenerative medicine. However, to avoid potential arrhythmias, it is critical that hESC-CMs used in replacement therapy be electrophysiologically compatible with the adult atrial, ventricular, and nodal phenotypes. The current method for classifying the electrophysiology of hESC-CMs relies mainly on the shape of the cell’s action potential (AP), which each expert subjectively decides if it is nodal-like, atrial-like or ventricular-like. However, the classification is difficult because the shape of the AP of an hESC-CMs may not coincide with that of a mature cell. In this paper, we propose to use ametamorphosis distancefor comparing the AP of an hESC-CMs to that of an adult cell model. This involves constructing a family of APs corresponding to different stages of the maturation process, and measuring the amount of deformation between APs. Experiments show that the proposed distance leads to better interpolation and classification results.