Rh(III) and Ir(III)Cp* Complexes Provide Complementary Regioselectivity Profiles in Intermolecular Allylic C-H Amidation Reactions
Rh(III) and Ir(III)Cp* Complexes Provide Complementary Regioselectivity Profiles in Intermolecular Allylic C-H Amidation Reactions
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DOI：
10.1021/acscatal.9b01338
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发表时间：
2019-06-01
期刊：
影响因子：
12.9
通讯作者：
Blakey, Simon B.
中科院分区：
文献类型：
--
作者：
Burman, Jacob S.;Harris, Robert J.;Blakey, Simon B.
开发了一种高效的区域选择性烯丙基C-H酰胺化单、二、三取代烯烃。具体来说，二恶唑酮试剂与RhCp*和IrCp*催化剂的组合被报道促进了与先前在pd催化和ag促进的rh催化反应中观察到的互补区域选择性的反应。我们报道了催化剂与底物类别的匹配对于选择性反应是必不可少的。RhCp*配合物对于β -烷基苯乙烯底物的高转化率和选择性是必需的，而IrCp*配合物对于未活化的末端烯烃是必需的。
An efficient regioselective allylic C-H amidation of mono-, di-, and trisubstituted olefins has been developed. Specifically, the combination of dioxazolone reagents with RhCp* and IrCp* catalysts is reported to promote reactions with complementary regioselectivites to those previously observed in Pd-catalyzed and Ag-promoted Rh-catalyzed reactions. We report that catalyst matching with substrate class is essential for selective reactions. RhCp* complexes are required for high conversion and selectivities with beta-alkylstyrene substrates, and IrCp* complexes are necessary in the context of unactivated terminal olefins.