IP-10, but not RANTES, is upregulated by leptin in monocytic cells
IP-10, but not RANTES, is upregulated by leptin in monocytic cells
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DOI：
10.1016/s1043-4666(02)00491-x
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发表时间：
2003-01-07
期刊：
影响因子：
3.8
通讯作者：
Dayer, JM
中科院分区：
文献类型：
--
作者：
Meier, CA;Chicheportiche, R;Dayer, JM
我们和其他人先前已经表明，瘦素对单核细胞和巨噬细胞的功能有直接影响。由于肥胖与心血管风险增加，以及与循环瘦素水平显着升高，我们研究是否瘦素有任何促炎作用的单核细胞的功能。瘦素强烈增强的表达和分泌的干扰素-γ-诱导蛋白（IP-10）在人单核细胞系，以及在外周血单核细胞。相比之下，没有观察到对其他炎症蛋白的显著影响，如金属蛋白酶和其他趋化因子。总之，我们已经证明，瘦素选择性地诱导IP-10在人类单核细胞的表达和分泌，可能有助于血管并发症与高瘦素血症肥胖的人。(C)2003爱思唯尔科技有限公司版权所有。
We and others have previously shown that leptin has direct effects on the function of monocytes and macrophages. Since obesity is associated with an increased cardiovascular risk, as well as with markedly elevated circulating leptin levels, we examined whether leptin has any pro-inflammatory effects on the function of monocytes.Leptin strongly enhanced the expression and secretion of the interferon-gamma-inducible protein (IP-10) in a human monocytic cell line, as well as in peripheral blood mononuclear cells. In contrast, no significant effect on other inflammatory proteins was observed, such as metalloproteinases and other chemokines.In summary, we have demonstrated that leptin selectively induces the expression and secretion of IP-10 in human monocytic cells, potentially contributing to the vascular complications associated with hyperleptinemic obesity in humans. (C) 2003 Elsevier Science Ltd. All rights reserved.