Severe psychiatric problems in right hepatic lobe donors for living donor liver transplantation
Severe psychiatric problems in right hepatic lobe donors for living donor liver transplantation
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DOI：
10.1097/01.tp.0000263343.21714.3b
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发表时间：
2007-06-15
期刊：
影响因子：
6.2
通讯作者：
Weinrieb, Robert M.
中科院分区：
文献类型：
--
作者：
Trotter, James F.;Hill-Callahan, Margaret M.;Weinrieb, Robert M.
背景活体肝移植（LDLT）中右肝叶捐赠的发病率和死亡率是该手术的一个重要问题。我们报告了成人间活体肝移植队列研究（A2ALL）中严重精神病术后并发症的患病率，该研究旨在确定LDLT对供体和受者的风险和益处。对1998年至2003年2月间接受评估的所有A2ALL研究的供者进行严重精神并发症评估。在392名供者中，16名（4.1%）有一种或多种精神并发症，包括三种严重的精神并发症（自杀、意外药物过量和自杀企图）。尽管进行了广泛的术前筛查，一些捐赠者在肝脏捐赠后会出现严重的精神并发症，包括自杀。对肝脏捐献者进行精神病学评估和监测可能有助于了解和预防此类悲剧事件。
Background. The morbidity and mortality from donation of a right hepatic lobe for living donor liver transplantation (LDLT) is an important issue for this procedure. We report the prevalence of severe psychiatric postoperative complications from the Adult-to-Adult Living Donor Liver Transplantation Cohort study (A2ALL), which was established to define the risks and benefits of LDLT for donors and recipients.Methods. Severe psychiatric complications were evaluated in all donors from the A2ALL study who were evaluated between 1998 and February 2003.Results. Of the 392 donors, 16 (4.1%) had one or multiple psychiatric complications, including three severe psychiatric complications (suicide, accidental drug overdose, and suicide attempt).Conclusions. Despite extensive preoperative screening, some donors experience severe psychiatric complications, including suicide, after liver donation. Psychiatric assessment and monitoring of liver donors may help to understand and prevent such tragic events.