Pascal panretinal laser ablation and regression analysis in proliferative diabetic retinopathy: Manchester Pascal Study Report 4
Pascal panretinal laser ablation and regression analysis in proliferative diabetic retinopathy: Manchester Pascal Study Report 4
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DOI：
10.1038/eye.2011.188
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发表时间：
2011-11-01
期刊：
影响因子：
3.9
通讯作者：
Stanga, P. E.
中科院分区：
文献类型：
--
作者：
Muqit, M. M. K.;Marcellino, G. R.;Stanga, P. E.
Aims To quantify the 20-ms Pattern Scan Laser（Pascal）panretinal laser photocoagulation（PRP）ablation dosage required for regression of proliferative diabetic retinopathy（PDR），and to explore factors related to long-term regression.Methods我们回顾性研究了一个队列的患者谁参加了一项随机临床试验，曼彻斯特帕斯卡研究。在18个月的随访期内，对22例患者的36只眼进行了研究。主要结局指标包括视力（VA）和完全PDR消退。次要结局包括激光烧伤剂量测定、视网膜PRP消融面积计算以及患者相关因素对疾病消退的影响。进行PDR亚组分析，以评估所有相关因素的PDR回归根据疾病severity. ResultsThere是没有显着变化的logMAR VA为任何组随着时间的推移。总共有10只眼睛（28%）在单次PRP后消退。补充PRP治疗后，消退率根据严重程度而变化：轻度PDR为75%（n = 6），中度PDR为67%（n = 14），重度PDR为43%（n = 3）。为了达到完全的疾病消退，轻度PDR需要平均2187次PRP烧伤和264 mm（2）消融面积，中度PDR需要3998次PRP烧伤和456 mm（2）消融面积，重度PDR需要6924次PRP激光烧伤（836 mm（2）; P
Aims To quantify the 20-ms Pattern Scan Laser (Pascal) panretinal laser photocoagulation (PRP) ablation dosage required for regression of proliferative diabetic retinopathy (PDR), and to explore factors related to long-term regression.Methods We retrospectively studied a cohort of patients who participated in a randomised clinical trial, the Manchester Pascal Study. In all, 36 eyes of 22 patients were investigated over a follow-up period of 18 months. Primary outcome measures included visual acuity (VA) and complete PDR regression. Secondary outcomes included laser burn dosimetry, calculation of retinal PRP ablation areas, and effect of patient-related factors on disease regression. A PDR subgroup analysis was undertaken to assess all factors related to PDR regression according to disease severity.Results There were no significant changes in logMAR VA for any group over time. In total, 10 eyes (28%) regressed after a single PRP. Following top-up PRP treatment, regression rates varied according to severity: 75% for mild PDR (n = 6), 67% for moderate PDR (n = 14), and 43% in severe PDR (n = 3). To achieve complete disease regression, mild PDR required a mean of 2187 PRP burns and 264 mm(2) ablation area, moderate PDR required 3998 PRP burns and area 456 mm(2), and severe PDR needed 6924 PRP laser burns (836 mm(2); P