Microglia: Architects of the Developing Nervous System.
Microglia: Architects of the Developing Nervous System.
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DOI：
10.1016/j.tcb.2016.02.006
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发表时间：
2016-08
影响因子：
19
通讯作者：
Schafer DP
中科院分区：
文献类型：
--
作者：
Frost JL;Schafer DP
小胶质细胞是中枢神经系统（CNS）的常驻巨噬细胞，占总CNS细胞的5-10%。最近的研究结果表明，小胶质细胞进入胚胎脑，在其他CNS细胞类型分化之前居住，并成为CNS发育的关键调节因子。在这里，我们讨论了令人兴奋的新工作牵连小胶质细胞在一系列的发展过程，包括调节细胞数量和空间格局的中枢神经系统细胞，髓鞘形成，形成和完善的神经回路。此外，我们回顾的研究表明，这些细胞功能可能会导致行为的调制，这对各种神经系统疾病有重要意义。
Microglia are resident macrophages of the central nervous system (CNS), representing 5–10% of total CNS cells. Recent findings reveal that microglia enter the embryonic brain, take up residence before the differentiation of other CNS cell types, and become critical regulators of CNS development. Here, we discuss exciting new work implicating microglia in a range of developmental processes including regulation of cell number and spatial patterning of CNS cells, myelination, and formation and refinement of neural circuits. Furthermore, we review studies suggesting that these cellular functions may result in modulation of behavior, which has important implications for a variety of neurological disorders.